Exquisitely preserved fossils left behind by creatures living more than half a billion years ago reveal in great detail identical structures that researchers have long hypothesized must have contributed to the archetypal brain that has been inherited by all arthropods. Arthropods are the most diverse and species-rich taxonomic group of animals and include insects, crustaceans, spiders and scorpions, as well as other, less familiar lineages such as millipedes and centipedes.
The fossils, belonging to an arthropod known as Leanchoilia, confirm the presence predicted by earlier studies in genetics and developmental biology of insect and spider embryos of an extreme frontal domain of the brain that is not segmented and is invisible in modern adult arthropods. Despite being invisible, this frontal domain gives rise to several crucial neural centers in the adult arthropod brain, including stem cells that eventually provide centers involved in decision-making and memory. This frontal domain was hypothesized to be distinct from the forebrain, midbrain and hindbrain seen in living arthropods, and it was given the name prosocerebrum, with "proso" meaning "front."
Described in a paper published today in the journal Current Biology, the fossils provide the first evidence of the existence of this discrete prosocerebral brain region, which has a legacy that shows up during the embryonic development of modern arthropods, according to paper lead author Nicholas Strausfeld, a Regents Professor of Neuroscience at the University of Arizona.
"The extraordinary fossils we describe are unlike anything that has been seen before," Strausfeld said. "Two nervous systems, already unique because they are identically preserved, show that half a billion years ago this most anterior brain region was present and structurally distinct before the evolutionary appearance of the three segmental ganglia that denote the fore-, mid- and hindbrain."
The term ganglion refers to a system of networks forming a nerve center that occurs in each segment of the nervous system of an arthropod. In living arthropods, the three ganglia that mark the three-part brain condensed together to form a solid mass, obscuring their evolutionary origin as segmented structures.
"The Kaili fossils open a window for us to glimpse the body plan evolution of animals that lived more than half a billion years ago," said the paper's first author, Tian Lan of the Guizhou Research Center for Palaeobiology at Guizhou University in China. "For the first time, we now know that arthropod fossils of the Kaili formation have the potential to preserve neural tissue that show us the primitive brain of the early stem arthropod existing at the dawn of the animal world."
"Nervous systems, as other soft tissues, are difficult to fossilize," added co-author Pedro Martinez of the Universitat de Barcelona and Institut Catal in Barcelona, Spain. "This makes the study of the early evolution of neural systems a challenging task."
The fossils also shed new light on the evolutionary origin of two separate visual systems in arthropod evolution: pairs of front-facing eyes or sideward looking eyes, the descendants of which are still present in species living today.
Many arthropods, including insects and crustaceans, have a distinct bilateral pair of faceted compound eyes and another set of less obvious eyes with more primitive architecture known as nauplius eyes, or ocelli. These are structurally similar to the principal eyes of spiders and scorpions. These simpler eyes correspond to the prosocerebrum's forward eyes in Leanchoilia, in line with evidence obtained by previous studies analyzing gene expression patterns during embryonic development of living arthropods.
Leanchoilia's sideward eyes, on the other hand, relate to the protocerebrum, which is the segmental ganglion defining the arthropod forebrain, lying just behind the prosocerebrum. In living arthropods, the protocerebrum provides the compound eyes of insects and crustaceans, or the lateral single-lens eyes of arachnids, centipedes and millipedes. The visual centers serving those eyes also belong to the brain's protocerebral region.
Strausfeld explained that in living arthropods, the protocerebrum, or forebrain, has incorporated in a way, swallowed up the ancient centers provided by the prosocerebrum, so that it is no longer discernible as a distinct anatomical entity.
The fossils are so well-preserved that they demonstrate that in addition to frontward eyes, the prosocerebrum has also given rise to ganglia associated with the labrum, or "upper lip," of modern arthropods. The fossils also confirm an earlier hypothesis suggesting that the labrum must have originally evolved from the grasping appendages of Radiodonta, a group of stem-arthropods that were top predators during the Cambrian period.
"When compared with other, similar fossil material belonging to more advanced lineages, the organization of the Leanchoilia brain demonstrates that the ganglionic arrangement of the early brain underwent condensation and fusion of its components, which explains why in living species the prosocerebrum cannot be individually distinguished," Strausfeld said.
Although simple, fishlike animals existed at the same time as these now-fossilized arthropods, there are no convincing fossils of their brains and, thus, neither fossil evidence nor anatomical evidence for a prosocerebrum in vertebrates. Yet, modern studies show that genes defining the fore- mid- and hindbrains of, for example, mice correspond to genes defining the three ganglionic divisions of the arthropod brain. And in vertebrates, certain crucial centers involved in decision making and in learning and memory have some genetic correspondences with the higher centers in the arthropod brain, which originated in the ancient arthropod prosocerebrum.
Thus, it is plausible that even earlier than the Cambrian period, possibly even before the evolution of segmentally organized body plans, the common ancestor of both vertebrates and invertebrates possessed basic circuits for simple cognition and decision making. And while an ancient prosocerebral-like brain might have been present in the very early ancestors of vertebrates, no such fossil has even suggested evidence for a discrete, nonsegmental domain.
"Nevertheless, one can reasonably speculate that vertebrates have embedded in their 'modern' brains parts of an ancient, non-segmented brain that has so far only been demonstrable in an early arthropod, such as Leanchoilia," Strausfeld said.Reference:Lan T, Zhao Y, Zhao F, He Y, Martinez P, Strausfeld NJ. Leanchoiliidae reveals the ancestral organization of the stem euarthropod brain. Curr Biol. 2021;0(0). doi:10.1016/j.cub.2021.07.048This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.
See original here:
What the Ancestral Brains of Arthropods Looked Like - Technology Networks
- Biology of stem cells: an overview - PMC - National Center for ... - March 26th, 2024
- Iron Limitation Preserves Youthfulness of Blood Stem Cells - Mirage News - March 13th, 2024
- Mini organs grown from stem cells of unborn babies for the first time in breakthrough - The Mirror - March 9th, 2024
- The Effect of Short-Term NAD3 Supplementation on Circulating Adult Stem Cells in Healthy Individuals Aged 40-70 ... - Cureus - March 7th, 2024
- University of Liverpool Spin-Out Emerges, Pioneering Novel Adult Stem Cell-Based Therapies - India Education Diary - March 7th, 2024
- Scientists have used cells from fluid drawn during pregnancy to grow mini lungs and other organs - Yahoo News Canada - March 6th, 2024
- Japan approves new stem cell-based Alzheimer's therapy By Proactive Investors - Investing.com Australia - January 20th, 2024
- Cyberstalking pits Harvard professor against PubPeer Retraction ... - Retraction Watch - December 5th, 2023
- 10 functional health predictions for 2024, according to a doctor and ... - 1330 WFIN - December 5th, 2023
- See the Brain Like Never Before in This Gorgeous Art - Scientific American - December 5th, 2023
- Geron Announces Publication in The Lancet of Results from the ... - BioSpace - December 5th, 2023
- Stem cell injections could be the key to curing MS - Freethink - December 3rd, 2023
- Jaypirca (pirtobrutinib) Now Approved by U.S. FDA for the ... - Investors | Eli Lilly and Company - December 3rd, 2023
- Comparative Efficacy and Safety of Four JAK Inhibitors for ... - HealthDay - December 3rd, 2023
- City lights up for Francis on Anthony Nolan's birthday - Liverpool Express - December 3rd, 2023
- NOT-AR-23-022: Request for Information on Themes for the NIAMS ... - National Institutes of Health (.gov) - December 3rd, 2023
- December 2023: Intramural Papers of the Month - Environmental Factor Newsletter - December 1st, 2023
- CNA Explains: What is cord blood banking and why do parents do it? - CNA - December 1st, 2023
- Regulation of myogenesis and adipogenesis by the electromagnetic ... - Nature.com - December 1st, 2023
- The effects of vitamin K on bone health - News-Medical.Net - December 1st, 2023
- Dr Hurwitz on Ongoing Investigations of the Use of CAR T-Cell ... - OncLive - December 1st, 2023
- Mitophagy in human health, ageing and disease - Nature.com - December 1st, 2023
- Adult Stem Cells - Stem Cells and the Future of Regenerative Medicine ... - November 29th, 2023
- Navigating The Regulatory Landscape Of Longevity Health Products ... - Mondaq News Alerts - November 29th, 2023
- MS breakthrough could lead to treatments that halt disease's ... - inews - November 29th, 2023
- Reprogramming tissue mechanically to promote wound healing - Phys.org - November 29th, 2023
- Latest Advances in Arthritis Diagnosis and Treatment at American ... - HealthDay - November 29th, 2023
- Sex-associated differences in frequencies and prognostic impact of ... - Nature.com - November 29th, 2023
- Hematologists Dive into the Current Treatment Landscape - OncLive - November 29th, 2023
- Team discovers protein crucial for B cell differentiation and antibodies - Phys.org - November 29th, 2023
- Science Talk - I survived cancer as a child and now I'm working to ... - The Institute of Cancer Research - November 29th, 2023
- First Edition: Nov. 29, 2023 - KFF Health News - November 29th, 2023
- Symptoms: Unilateral Hearing Loss and Tinnitus : The Hearing Journal - LWW Journals - November 29th, 2023
- Mitigation of sepsis-induced acute lung injury by BMSCs | IJN - Dove Medical Press - November 29th, 2023
- A Case of a Constricted Vessel: The Impact of Acute Myeloid ... - Cureus - November 29th, 2023
- Mum brushed off fatigue after having baby but fall sparked deadly diagnosis - The Mirror - November 29th, 2023
- How heritable is the epigenome? - Drug Discovery News - November 29th, 2023
- The Blueprint of Regeneration: Scientists Discover How to Turn Stem Cells Fate - Revyuh - November 27th, 2023
- BrainStorm Cell Therapeutics Announces In-Person Meeting with ... - Marketscreener.com - November 27th, 2023
- Stem Cell Therapy Developed in Korea Begins Treatment for ... - PharmiWeb.com - November 25th, 2023
- COVID-19 Pandemic's Adverse Effect on Bone Health in Young ... - HealthDay - November 25th, 2023
- Sickle cell breakthrough - The Indian Express - November 25th, 2023
- Wall thickness analysis method for judging the degree of lower ... - Nature.com - November 25th, 2023
- Century Therapeutics to Present at the Piper Sandler 35th Annual Healthcare Conference - Yahoo Finance - November 23rd, 2023
- Disease Transmission and Diagnosis of Zika Virus - Cureus - November 23rd, 2023
- Gene-editing therapy for sickle cell earns conditional approval in UK - Sickle Cell Disease News - November 23rd, 2023
- Stem Cell Therapy Developed in Korea Begins Treatment for ... - Newswire - November 21st, 2023
- Efficacy of ADSC-CM in Patients with Telogen Effluvium | SCCAA - Dove Medical Press - November 21st, 2023
- BrainStorm Cell Therapeutics Announces In-Person Meeting with ... - PR Newswire - November 21st, 2023
- The Impact of CAR T Cell Therapy on Managing R/R LBCL - OncLive - November 21st, 2023
- Mansour bin Zayed witnesses inauguration of ADSCC Bone Marrow Transplant & Cellular Therapy Congress 2023 - ZAWYA - November 21st, 2023
- Listeria: Who is most susceptible? What are the Symptoms? What ... - Food Poison Journal - November 21st, 2023
- Scope Of Issued Patents May Be Limited By Prosecution Estoppel ... - Mondaq News Alerts - November 21st, 2023
- Qrons Announces the Addition of Professor Shiri Navon-Venezia to ... - StreetInsider.com - November 21st, 2023
- Financially strapped Athersys raises $10.4M - cleveland.com - November 19th, 2023
- From the India Today archives (2010) | How stem cells can save your life - India Today - November 19th, 2023
- Inactivation of the tumor suppressor gene Apc synergizes with H ... - Science - November 19th, 2023
- The Origins of Multiple Myeloma and Why it Matters - HealthTree For AML - Acute Myeloid Leukemia - November 19th, 2023
- Treatment Considerations With TROP2-Targeted Therapy - OncLive - November 19th, 2023
- Athersys narrows loss, raises $10.4 million during third quarter to ... - The Business Journals - November 17th, 2023
- Who was Dolly the Sheep and what happened to her? The story of ... - BBC Countryfile Magazine - November 17th, 2023
- UK first to approve CRISPR treatment for diseases: what you need to ... - Nature.com - November 17th, 2023
- 1st sickle cell patient to be given therapy restoring fetal hemoglobin - Sickle Cell Disease News - November 15th, 2023
- Century Therapeutics Reports Third Quarter 2023 Financial Results and Provides Business Updates - Century - Benzinga - November 13th, 2023
- Century Therapeutics Appoints Brent Pfeiffenberger, Pharm.D., MBA, as Chief Executive Officer - Yahoo Finance - November 11th, 2023
- Century Therapeutics and FUJIFILM Cellular Dynamics Announce Licenses for the Development and Commercialization of iPSC-Derived Cell Therapies in... - November 11th, 2023
- AAO 2023: Paul Runge and his ROP treatments in the Ukraine - Modern Retina - November 11th, 2023
- The Evolutionary Reasons We Are Drawn To Horror Movies and ... - Slashdot - November 11th, 2023
- Century Therapeutics Reports Third Quarter 2023 Financial Results ... - GlobeNewswire - November 11th, 2023
- Century Therapeutics Reports Third Quarter 2023 Financial Results ... - StreetInsider.com - November 9th, 2023
- NYU Langone Health Performs World's First Whole-Eye & Partial ... - NYU Langone Health - November 9th, 2023
- BrainStorm to Announce Third Quarter 2023 Financial Results and ... - BioSpace - November 9th, 2023
- Can we cut cost and pain of IVF? Start-up CEO tries out own ... - Genetic Literacy Project - November 9th, 2023
- Jasper Therapeutics Reports Third Quarter 2023 Financial Results ... - BioSpace - November 9th, 2023
- Impaired neural stress resistance and loss of REST in bipolar ... - Nature.com - November 9th, 2023
- Functional genomics and systems biology in human neuroscience - Nature.com - November 9th, 2023
- Trial launched to test CAR T-cell therapy in dogs diagnosed with ... - EurekAlert - November 9th, 2023
- The-Gut's-Lasting-Impact-on-Severe-COVID-19-Immune-Response - Infectious Disease Special Edition - November 9th, 2023
- Emerging Cure for Sickle Cell on its Way to FDA Approval, Carries ... - Dallasweekly - November 7th, 2023
- The science works, but will we pay for it? - Irish Medical Times - November 7th, 2023
Recent Comments