Cord Blood Stem Cells Market Growth, Analysis of Key Players, Trends, Drivers – Khabar South Asia

Market Study Report, LLC, has expanded its reports database with a new research study on Cord Blood Stem Cells market which features a precise summary of the business valuation, SWOT Analysis, market size, revenue estimation and regional viewpoint of this business vertical. Moreover, the report accurately features significant opportunities and obstacles awaiting contenders of this industry and enlighten the present competitive landscape and corporate strategies adopted by Cord Blood Stem Cells market players.

The Cord Blood Stem Cells market report provides a granular assessment pertaining to the key development trends and dynamics impacting this industry landscape over the analysis timeframe. It offers significant inputs with respect to the regulatory outlook as well as geographical landscape of this business space. The study also elaborates on the factors that are positively influencing the overall market growth and encloses a detailed SWOT analysis. Additionally, the document comprises of limitations & challenges impacting the future remuneration and y-o-y growth rate of this market.

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The report offers an in-depth analysis of the competitive landscape alongside raw materials and downstream buyers of Cord Blood Stem Cells market. Moreover, the study assesses the effect of COVID-19 pandemic on the growth opportunities of this industry vertical.

Expanding on the regional analysis of the Cord Blood Stem Cells market:

Elaborating on the competitive landscape of Cord Blood Stem Cells market:

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The report answers important questions that companies may have when operating in the global Cord Blood Stem Cells market. Some of the questions are given below:

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Cord Blood Stem Cells Market Growth, Analysis of Key Players, Trends, Drivers - Khabar South Asia

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Placental Stem Cells (PSCS) Market 2020-2027 to Show Tremendous Growth || Leading Players StemCyte India Therapeutics Pvt. Ltd, PerkinElmer Inc,…

In Placental Stem Cells (PSCS) Market report, a systematic investment analysis has been performed which forecasts impending opportunities for the market players. The statistical and numerical data that has been included in this market report is represented with the tables, graphs and charts which eases the understanding of facts and figures. A proficient data and excellent forecasting techniques used in this report are synonymous with accurateness and correctness. Placental Stem Cells (PSCS) Market report is a painstaking analysis of existing scenario of the market which covers several market dynamics. The market study of this global Placental Stem Cells (PSCS) Market business report takes into consideration market attractiveness analysis where each segment is benchmarked based on its market size, growth rate & general attractiveness.

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Placentalstem cells(PSCS) market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to growing at a CAGR of 10.25% in the above-mentioned forecast period. Increasing awareness regarding the benefits associates with the preservation of placental derived stem cells will boost the growth of the market.

The major players covered in theplacental stem cells (PSCS) marketreport areCBR Systems, Inc, Cordlife India, Cryo-Cell International, Inc., ESPERITE N.V., LifeCell International Pvt. Ltd., StemCyte India Therapeutics Pvt. Ltd, PerkinElmer Inc, Global Cord Blood Corporation., Smart Cells International Ltd., Vita 34, among other domestic and global players. Market share data is available for Global, North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South America separately.DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

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Market Analysis and Insights of Global Placental Stem Cells (PSCS) Market

Adoption of advances and novel technologies that will lead to the storage and preservation of stem cells, technological advancement in the field of biotechnology, introduction of hematopoietic stem cell transplantation system and growing number of diseases which will helps in accelerating the growth of the placental stem cells (PSCS) market in the forecast period of 2020-2027. Surging number of applications from emerging economies along with rising awareness among the people will further boost many opportunities that will led to the growth of the placental stem cells (PSCS) market in the above mentioned forecast period.

Increasing operation costs along with stringent regulatory framework will likely to hamper the growth of the placental stem cells (PSCS) market in the above mentioned forecast period. Social and ethical issues will be the biggest challenge in the growth of the market.

Thisplacental stem cells(PSCS) market report provides details of new recent developments, trade regulations, import export analysis, production analysis, value chain optimization, market share, impact of domestic and localised market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market. To gain more info on placental stem cells (PSCS) market contactData Bridge Market Researchfor anAnalyst Brief, our team will help you take an informed market decision to achieve market growth.

Global Placental Stem Cells (PSCS) Market Scope and Market Size

Placental stemcells(PSCS) market is segmented on the basis of service type and application. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.

Placental Stem Cells (PSCS) Market Country Level Analysis

Placental stemcells(PSCS) market is analysed and market size insights and trends are provided by country, service type and application as referenced above.

The countries covered in the placental stem cells (PSCS) market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

North America dominates the bone marrow-derived stem cells (BMSCS) market due to the increasing stem cell procedure along with preferences of private stem cell banking over public and surging network of stem cell banking services.

The country section of the placental stem cells (PSCS) market report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points such as consumption volumes, production sites and volumes, import export analysis, price trend analysis, cost of raw materials, down-stream and upstream value chain analysis are some of the major pointers used to forecast the market scenario for individual countries. Also, presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.

Healthcare Infrastructure growth Installed base and New Technology Penetration

Placental stem cells (PSCS) market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipments, installed base of different kind of products for placental stem cells (PSCS) market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the placental stem cells (PSCS) market. The data is available for historic period 2010 to 2018.

Competitive Landscape and Placental Stem Cells (PSCS) Market Share Analysis

Placental stem cells (PSCS) market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies focus related to placental stem cells (PSCS) market.

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Placental Stem Cells (PSCS) Market 2020-2027 to Show Tremendous Growth || Leading Players StemCyte India Therapeutics Pvt. Ltd, PerkinElmer Inc,...

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Vitalant to Hold Blood Donation Event on December 5 in Freehold – TAPinto.net

Increased Need for Blood Donations throughout Monmouth County during Nationwide COVID-19 Surge

MONTVALE, NJ Due to thenationwide surge in COVID-19 infections, along with the usual drop-offin donations at the beginning of the holiday season, theres now a particularly severe blood shortage.

In response, the nonprofit, blood-collection organization Vitalant is providing a local, open-to-the-public donation event on Saturday, December 5 from 8 a.m. to 1 p.m. at the Knights of Columbus, 70 East Main Street, Freehold.

Our newsletter delivers the local news that you can trust.

Individuals who have recovered from COVID-19 are urged to donate blood plasma. Known as convalescent plasma, this blood component contains antibodies that may provide seriously ill patients an extra boost in fighting the disease. There is also a great need for blood platelets small cells in the blood that form clots to prevent bleeding, while also helping with anemia and low blood counts and type O-negative, the universal blood type.

FEMA has specifically identified blood donation as an essential and integral component of the emergency support function. Of note, coronavirus cannot be transferred through the blood. And, as always, the blood collection process is safe with no impact on the donor's immune system. Vitalant staff follows rigorous safety and disinfection protocols at its blood drives and donation centers and have always required individuals to be in good health to donate blood.

Vitalant also maintains four New Jersey blood centers, with hours and street addresses as follows:

Healthy individuals age 16 or older, who weigh at least 110 pounds, may donate blood; 16- and 17-year-olds must have proof of birth date and signed consent forms, either in English (http://www.communitybloodservices.org/media/Minor_Donor_Permit_ENG.pdf) or Spanish (http://www.communitybloodservices.org/media/Minor_Donor_Permit_Form_SP.pdf). Donors should eat a moderate meal prior to donating, and also bring identification featuring their signature.

On occasion, last-minute changes to scheduling for a donation event will occur. As a result, it is recommended that anyone planning to donate blood at a Vitalant donation event call 201-251-3703, toll free, to confirm timing and location details. Additional information about donating blood is also available by visitingwww.vitalant.org.

Vitalant has initiated a multiweek incentive program to attract additional donations at its New Jersey donation centers. Specifics are as follows:

December 23 January 1

All donors will receive a Vitalant T-shirt or 200 bonus pointstoward exclusive rewards through Vitalants online store.

About Vitalant in New Jersey

A not-for-profit organization that supplies blood and blood products to hospitals in the NJ/NY region, Bergen County-based Vitalant (previously Community Blood Services) has been devoted to serving the communitys transfusion medicine needs since 1953. Donations of blood and blood products, umbilical cord blood, stem cells, and bone marrow help to join individuals, organizations, businesses, and entire communities together in partnership to help save lives.

About Vitalant

Arizona-based Vitalant is among the nations oldest and largest transfusion medical organizations in the U.S. Founded in 1943, its blood centers division serves some 700 hospitals across the United States. A founding member of Americas Blood Centers and the AABB (formerly the American Association of Blood Banks), Vitalant also operates biological products distribution services, a quality consulting group, and a world-renowned transfusion medicine research institute. It also is a partner in the operation of high-volume donor testing laboratories.

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Research Antibodies Market is Driven by Increasing Incidence of Chronic Diseases and Life-threatening Diseases – Cheshire Media

Global Research Antibodies Market: Overview

The global research antibodies market is anticipated to rise at a notable pace over the forecast period. Antibodies display exceptional physiological properties that make them sought-after for cell research.

Antibodies display other properties too. As they have the ability to attach to specific molecules, this enables specific molecules to be isolated for research. Hence, this makes for a key factor for continual research to examine the physiology and anatomy of antibodies.

The report serves to identify prevailing growth trends based on which projections made. The report constitutes most relevant data pertaining to comprehend the growth dynamics of research antibodies market. Geographical distribution of the research antibodies market and an analysis of the competitive structure are highlights of the report.

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Global Research Antibodies Market: Key Trends

Currently, pharmaceutical and biopharmaceutical companies are undertaking extensive R&D activities to introduce novel products. These pursuits involve widespread use of antibodies because of their exceptional physiological properties. Therefore, research on antibodies receives a boost for their use in secondary cell research.

Pharmaceutical giants are also making hefty investments for advancement of antibodies research.

Increasing incidence of chronic diseases and life-threatening diseases such as cancer has led to extensive initiatives for advanced therapeutics. Pharmaceutical and biotechnology companies are making efforts in terms of upgrading their R&D capability and pumping money. These efforts are aimed to develop advanced therapeutics as well as personalized medicine for a gamut of chronic and fatal diseases. These factors collectively bode well for research antibodies market.

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At present, stem cell research is finding keen interest of researchers and geneticists. Several studies support the efficacy of stem cell for blood cancers, blood and bone marrow diseases, immune disorders. Lately, stem cells from the umbilical cord and stem cells from the blood stream have been used to treat rare blood related diseases. Due to the dependency an antibodies for stem cell research, researchers are involved to isolate different antibodies molecules. This is aiding growth of research antibodies market.

Lastly, novel use of antibodies that are receiving acceptance of accredited bodies is serving to boost the research antibodies market. For example, in a new development, FDA approved the clinical application of DNA-encoded monoclonal antibody therapy as a prevention against Zika virus.

Global Research Antibodies Market: Regional Analysis

The global research antibodies market is spread across North America, Asia Pacific, Europe, Latin America, and the Middle East & Africa. Among them, North America holds supremacy in the overall market. The region being home to large biotechnology and biopharmaceutical companies, along with immense government aid for research are key factors behind exceptional growth of North America antibodies market.

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Stringent regulations in place for manufacturers of antibodies and due adherence to these regulations accounts for high quality products from the region. This further pushes the North America research antibodies market.

On the other hand, Asia Pacific is emerging as a key region for research antibodies. Increasing R&D for antibodies and adoption of novel techniques for the production of antibodies is serving to fuel the region.

Global Research Antibodies Market: Competitive Outlook

Prominent players in the global research antibodies market include Abcam plc, Agilent Technologies, and Thermo Fisher Scientific Inc.

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Research Antibodies Market is Driven by Increasing Incidence of Chronic Diseases and Life-threatening Diseases - Cheshire Media

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The roles bone marrow plays in the body – Therogersvillereview

Bones make up the skeletal system and serve the important function of giving the body support to be able to move. Whats inside the bones also is essential to personal health.

Bone marrow can be found in the center of bones. According to the online wellness resource Healthline, this viscous or spongy tissue comes in two types: red or yellow bone marrow. Both have specific functions in the body.

Red bone marrow is essential for a process called hematopoiesis, or blood cell production. Hematopoietic stem cells in the red bone marrow can develop into key blood cells, including red blood cells, which carry oxygen-rich blood to the body; platelets, which help blood to clot; and white blood cells, which are involved in immune system responses.

Yellow bone marrow is involved with the storage of fats. These fats can be used as an energy source as needed. Yellow bone marrow also contains mesenchymal stem cells that can develop into bone, fat, muscle, or cartilage cells.

Over time, yellow bone marrow replaces red bone marrow in most of the bones in the adult body. Only a few bones, such as the pelvis, skull, vertebrae, and ribs, will contain red bone marrow into adulthood.

According to Medical News Today, bone marrow makes more than 200 billion new blood cells every day. Most blood cells in the body develop from bone marrow cells.

Issues with bone marrow can produce a host of side effects. Fatigue or weakness, fever, increased infections, easy bleeding and bruising, and specific conditions like leukemia and anemia can develop as a result of bone marrow-related problems. In some cases, a bone marrow transplant may be needed to replace diseased or nonfunctioning bone marrow. It also may help regenerate a new immune system that can fight leukemia or other cancers.

Bone marrow transplants also may involve replacing existing bone marrow with genetically healthy bone marrow to prevent future damage from certain genetic diseases, according to Medical News Today. Bone marrow transplants can come from ones own stem cells, a twin, a sibling, parent, or an unrelated donor. Marrow transplants also may come from stored umbilical cord blood.

Bone marrow is vital to the overall health and function of the human body. Bone marrow affects just about every other cell due to its unique relationship with blood production and immune function.

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Revenue from the Sales of Hematopoietic Stem Cells Transplantation Market to Witness Relatively Significant Growth During 2017 2025 – Canaan Mountain…

Hematopoietic stem cells are young or immature blood cells found to be living in bone marrow. These blood cells on mature in bone marrow and only a small number of these cells get to enter blood stream. These cells that enter blood stream are called as peripheral blood stems cells. Hematopoietic stem cells transplantation is replacement of absent, diseased or damaged hematopoietic stem cells due to chemotherapy or radiation, with healthy hematopoietic stem cells. Over last 30 years hematopoietic stem cells transplantation market seen rapid expansion and constant expansion with lifesaving technological advances. Hematopoietic stem cells transplantation is also known blood and marrow transplantation which brings about reestablishment of the patients immune and medullary function while treating varied range of about 70 hematological and non-hematological disorders. In general hematopoietic stem cells transplantation is used in treatment of hereditary, oncological, immunological and malignant and non-malignant hematological diseases.

There are two types of peripheral blood stem cell transplants mainly autologous and allogeneic transplantation. In autologous transplants patients own hematopoietic stem cells are harvested or removed before the high-dose treatment that might destroy the patients hematopoietic stem cells. While in allogeneic transplants stem cells are obtained from a tissue type of matched or mismatched donor. Hematopoietic stem cells are harvested from blood or bone marrow and is then frozen to use later. Depending upon the source of hematopoietic stem cells, worldwide there are three types of hematopoietic stem cells transplants namely bone marrow transplant (BMT), peripheral blood stem cell transplant and cord blood transplant. Major drivers in the hematopoietic stem cells transplantation market are establishment of strong and well developed network of hematopoietic stem cells transplantation organizations having global reach and presence has recognized NGO named Worldwide Network for Blood and Marrow Transplantation Group (WBMT) in official relation with World Health Organization (WHO) and rapid increase in number of transplants. Major restraints in hematopoietic stem cells transplantation market is high cost of transplantation and lack of funding for WBMT and other organizations such as regional, national and donor.

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The global market for Hematopoietic stem cells transplantation market is segmented on basis of transplant type, application, disease indication, end user and geography:

Based on transplantation type, hematopoietic stem cells transplantation market is segmented into allogeneic and autologous. Hematopoietic stem cells transplantation market is also segmented by application type into bone marrow transplant (BMT), peripheral blood stem cell transplant and cord blood transplant. The market for hematopoietic stem cells transplantation is majorly driven by bone marrow transplant (BMT) segment. Based on end user hematopoietic stem cells transplantation market is segmented into hospitals and specialty centers. Peripheral blood stem cell transplant type holds the largest market for hematopoietic stem cells transplantation. Hematopoietic stem cells transplantation market is further segmented by disease indication into three main categories i.e. lymphoproliferative disorders, leukemia, and non-malignant disorders. Segment lymphoproliferative disorder holds largest share amongst the three in Hematopoietic stem cells transplantation market. On the basis of regional presence, global hematopoietic stem cells transplantation market is segmented into five key regions viz. North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. Europe leads the global hematopoietic stem cells transplantation market followed by U.S. due to easy technological applications, funding and high income populations. Other reasons for rise in hematopoietic stem cells transplantation market is high prevalence of lymphoproliferative disorders and leukemia; demand for better treatment options; and easy accessibility and acceptance of population to new technological advances. Transplantation rates in high income countries are increasing at a greater extent but continued rise is also seen in low income countries and expected to rise more. Hematopoietic stem cells transplantation market will have its potential in near future as being a perfect alternative to traditional system in many congenital and acquired hematopoietic disorders management. While India, China and Japan will be emerging as potential markets. An excellent and long term alternative to relief by side effects of chemotherapy, radiotherapy and immune-sensitive malignancies is another driver for hematopoietic stem cells transplantation market. The key players in global hematopoietic stem cells transplantation market are Lonza, Escape Therapeutics, Cesca Therapeutics Inc., Regen BioPharma, Inc., Invitrx Inc, StemGenex, Lion Biotechnologies, Inc., CellGenix GmbH, Actinium Pharmaceuticals, Inc., Pluristem, Kite Pharma, Novartis AG.

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Revenue from the Sales of Hematopoietic Stem Cells Transplantation Market to Witness Relatively Significant Growth During 2017 2025 - Canaan Mountain...

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Global Stem Cells Market is estimated to account for US$ 18289.9 Mn by end of 2027, Says Coherent Market Insights (CMI) – Business Wire

SEATTLE--(BUSINESS WIRE)--The cells of the body are made up of the same basic components, namely: Blood, Muscle, Nerve, Brain, Gut, Respiratory, Skin, Cardiovascular, Urine, and Stem Cells. Each of these cells is unique in its characteristics but all of them play an important role in how healthy your body is and how well it functions.

Blood cells are made up of red blood cells (erythrocytes), platelets (platelet-activating factor) and neutrophils (killer T cells). Unlike blood cells in other organs of the body, white blood cells (white blood cells) do not multiply: they only act as a defense mechanism for the body in the fight against infection and in keeping your immune system active. Blood cells can also be converted to other cells such as platelets and plasma by the action of the protein platelet-activating factor (PAF). When a platelet or plasma cell reproduces, it becomes another cell: a daughter cell. The daughter cell then either becomes a blood cell or goes on to differentiate into a different type of cell such as a red blood cell or a platelet.

The global stem cells market is expected to account for US$ 9941.2 Mn in 2020 in terms of value and is expected to grow at a CAGR of 9.1% during forecast 2020-2027.

Market Drivers:

High prevalence of cancer is expected to propel growth of the global stem cells market over the forecast period. For instance, according to the American Cancer Society, in 2019, there will be an estimated 1,762,450 new cancer cases diagnosed and 606,880 cancer deaths in the U.S.

Moreover, developments towards boosting the availability and use of induced pluripotent stem cell technology is also expected to aid in growth of the market. For instance, in November 2020, FUJIFILM Cellular Dynamics, Inc. partnered with Lonza Walkersville, Inc. to enable drug developers to leverage both companies expertise and technologies for the generation of human induced pluripotent stem cells through licensing agreements.

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Market Opportunities

Potential of stem cell therapy in the treatment of Covid-19 is expected to offer lucrative growth opportunities for players in the global stem cells market. For instance, in November 2020, the randomised, controlled Phase III trial of remestemcel-L in patients with moderate to severe acute respiratory distress syndrome (ARDS) due to COVID-19 infection has been advised to continue by the independent Data Safety Monitoring Board (DSMB).

Moreover, increasing funding for R&D in stem cell therapy is also expected to aid in growth of the market. For instance, in November 2020, Californias stem cell agency will receive an infusion of US$ 5.5 billion in new research funding after voters approved Proposition 14. Similarly, in November 2020, California Institute for Regenerative Medicine awarded a US$ 9 million grant to Diana Farmer and Aijun Wang to help launch the worlds first human clinical trial using stem cells to treat spina bifida, a birth defect that occurs when the spine and spinal cord dont form properly.

Market Trends

Major players operating in the global stem cells market are focused on R&D to expand their product portfolio. For instance, in November 2020, IMAC Holdings, Inc. announced that the company is opening enrollment in its Phase 1 clinical trial for its investigational compound utilizing umbilical cord-derived allogenic mesenchymal stem cells for the treatment of bradykinesia, or the gradual slowing and loss of spontaneous body movement, due to Parkinsons disease.

Competitive Landscape:

Major players operating in the global stem cells market include, Advanced Cell Technology, Inc., FUJIFILM Cellular Dynamics, Inc., Angel Biotechnology Holdings PLC, Bioheart Inc., Lineage Cell Therapeutics., BrainStorm Cell Therapeutics, Inc., IMAC Holdings, Inc., California Stem Cell Inc., Celgene Corporation, Takara Bio Europe AB, Cellular Engineering Technologies, Cytori Therapeutics Inc., Osiris Therapeutics, and STEMCELL Technologies Inc.

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Global Stem Cells Market is estimated to account for US$ 18289.9 Mn by end of 2027, Says Coherent Market Insights (CMI) - Business Wire

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Community Cord Blood Banking emerges as a lifesaver – India Education Diary

Bangalore: India achieves a major milestone in the field of stem cell transplants. Community Cord Blood Banking, a unique and innovative stem cell banking initiative that was introduced by LifeCell in 2017, helped save a seven-year-old girl suffering from aplastic anaemia a rare and serious blood disorder when all other possible treatments failed.

A team of senior doctors from LOTUS Institute of Haematology, Oncology and Bone Marrow Transplantation, successfully conducted a double unit cord blood transplant to save the life of the child from Nashik in Maharashtra. This transplant was, in particular, challenging because there were no appropriate bone marrow donors and the cost of retrieval of matching units from public cord blood banks would have been quite high. As members of LifeCell Community Bank, the parents placed a matching request for two cord blood units after the childs sibling was found to be only a 50% (4/8) match. Two high-quality matches () were found in the registry, which fulfilled the requirement for Umbilical Cord Blood (UCB) transplantation. Importantly, the parents could withdraw these matched units at no additional expense, which otherwise would cost not less than Rs. 45,00,000/unit, according to a 2011 study analysing the cost of UCB transplantation in India.

Elaborating on this milestone, Mr. Mayur Abhaya, MD, LifeCell International said, The purpose of Community Cord Blood Banking is to ensure easy and rapid access to stem cells for every Indian without the hurdles of public and private banking models. While stem cells from the umbilical cord blood can be procured from global public banks, the probability of finding a match for a patient of Indian origin is less than 10% because of the low inventory of available units plus the big issue of donor dropouts. Luckily, since the family was a part of LifeCells community banking program, they could gain quick, free access to the huge inventory of over 50,000 qualified and consented units available at LifeCell which provides greater than 97% probability of finding a match.

In the majority of the blood-related disorders treatable by transplants, patients own stem cells are not suitable. Hence, the best donor is a close family member, usually a sibling. However, in this particular case, there was only a 50% match with the sibling and thats why a high-quality match from an unrelated donor was crucial for a successful transplant. While a regular stem cell transplant requires a dose of 25 million cells per kg of patient weight, for aplastic anaemia the recommended minimum dose is 40 million cells per kg and thats not easy to find. The community banking model made it possible and the child received a timely transplant with an encouraging prognosis. Just 18 days after the transplant, white blood cells completely engrafted, and platelets and red blood cell production also increased drastically.

Calling it a real social service by LifeCell, Dr. Pritesh Junagade, Director of LOTUS Hospital said, that he was pleasantly surprised that the retrieval process for two cord blood units was convenient and at no additional cost to the patient as compared to other banking models. He is now a supporter of LifeCells community banking and would welcome the opportunity to further advance this initiative.

Speaking about the transplant, Mr Tasneem Bohari, It was two years ago that my daughter was diagnosed with aplastic anaemia. At the time of diagnosis, the doctors had suggested she would need a stem cell transplant eventually and it would be the best possible treatment in the future. We made several research and enquiry about which stem cell bank to opt for as we were expecting our second baby. It was during this time, our friends and relatives had suggested LifeCell and we consulted our doctor as well who also said we could go ahead and preserve our babys stem cell with LifeCell. At the time of preservation, we didnt have much idea on community stem cell banking and its benefits but today we are happy to associate with LifeCell who have helped my daughter lead a quality life through cord blood transplant.

Commenting on the Community Cord Blood Banks historical moment, Mr. Ishaan Khanna, CEO Biobank and Diagnostics, LifeCell International Pvt. Ltd. said, Community Cord Blood Banking is a visionary initiative of our MD, Mr. Mayur Abhaya that will increase the scope of stem cell transplants to treat life-threatening diseases for Indians worldwide. I am pleased to say that our promise to ensure world-class preventive healthcare is kept today and the future holds greater potential for more such innovative stem-cell-based therapeutic solutions. This development is indeed very encouraging for the medical community and every Indian.

Community Cord Blood Banking is a unique initiative of LifeCell, which allows sharing of preserved umbilical cord stem cells from a common pool amongst the members of the community. The model offers greater and easier access to donor stem cells, unlimited retrievals at the cost of one enrolment, and a higher probability for finding a close match for potentially life-saving treatments. Community banking, thus, ensures complete protection to the child, siblings, parents, and maternal & paternal grandparents from more than 80 disorders treatable by stem cells.

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Community Cord Blood Banking emerges as a lifesaver - India Education Diary

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Septic shock and pneumonia triggered by SARS-CoV-2 could be treated by radiation-activated MSCs – News-Medical.Net

Reviewed by Emily Henderson, B.Sc.Nov 23 2020

This study, published in the journal Cells, is based on others (all of which employed experimental models) previously conducted by researchers at the Biomedical Research Centre of the University of Granada, the Lpez-Neyra Institute of Parasitology and Biomedicine, and the Virgen de las Nieves University Hospital in Granada

The results are still a long way from being applied to sick patients, for scientific and ethical reasons, the UGR researchers explain.

Scientists from the University of Granada (UGR) and the Virgen de las Nieves University Hospital in Granada have found that a combination of basal mesenchymal stem cells (MSCs) and radiation-activated MSCs could be used to treat septic shock and pneumonia triggered by SARS-CoV-2, the coronavirus that causes COVID-19.

This study, which builds on others previously conducted by researchers at the Biomedical Research Centre of the University of Granada, the Lpez-Neyra Institute of Parasitology and Biomedicine, and the Virgen de las Nieves University Hospital in Granada, was published recently in the journal Cells. However, the results remain a long way from being applied to sick patients, for scientific and ethical reasons, according to the researchers.

MSCs are a type of stem cells present in a wide variety of tissues (bone marrow, blood from the human umbilical cord, skin, adipose tissue or muscle tissue, for instance). They are capable of producing different specialized cells found in the tissues of the body human. For example, they can differentiate (or specialize) into cartilage cells (chondrocytes), bone cells (osteoblasts), and fat cells (adipocytes).

In response to the COVID-19 pandemic, numerous research groups around the world believe it is possible to increase peoples biological resistance to SARS-CoV-2 by using MSC-based therapeutic procedures. At present, there are also many clinical trials underway to verify the results of this type of cell therapy among COVID-19 patients.

In previous studies, scientists from the UGRs Biomedical Research Centre (CIBM) have demonstrated that the combination of radiation therapy and radiation- activated MSCs dramatically reduces the size of tumors implanted in murine research models (strains of mice), both in the irradiated tumor and in its metastasis.

These findings have led us to conclude that radiation-activated MSCs enhance the action of radiotherapy through the secretion of microvesicles and proteins into the extracellular medium. From there, either free or encapsulated in minuscule structures called exosomes, they reach tumor sites located at a distance from the irradiated tumor and exert powerful antitumor effects.

Ruiz de Almodvar

Among the substances secreted by the activated MSCs, researchers have been able to identify exosomes heavily loaded with annexin A1 as elements potentially responsible for tumor radiosensitization. The annexin A1 protein is being widely studied in infection, inflammation, and hypoxia scenarios, and its therapeutic applications have been extensively documented by the researchers who conducted the present study (reference 1).

Knowing of the pharmacological properties of annexin A1 and the epithelial and endothelial wound-healing functions characteristic of mesenchymal cells, we believe that the combination of their different actions may be supremely important in the treatment of septic shock and pneumonia caused by SARS-CoV-2 infection, explains Ruiz de Almodvar.

He continues: We therefore anticipate that the simultaneous administration of both treatments (basal MSCs and radiation-activated MSCs) can facilitate control of the infection and inflammation processes in the lung and, by exosome transfer via blood and lymphatic flow, solve or mitigate the problems of disseminated intravascular coagulation and sepsis, which cause multiple organ dysfunction syndrome and are life-threatening among patients severely affected by COVID-19.

The researchers from the UGR and the Virgen de las Nieves Hospital emphasize that these results are simply a hypothesis and we need to carry out more experimental work and secure official approval of the treatment. But, as soon as we are sure that treatment with radiation-activated MSCs is safe and effective, we will be able to offer this cell therapy to patients affected by COVID-19.

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Septic shock and pneumonia triggered by SARS-CoV-2 could be treated by radiation-activated MSCs - News-Medical.Net

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Community Cord Blood Banking saves life of child with aplastic anaemia – The Hindu

Community Cord Blood Banking, a stem cell banking initiative introduced by LifeCell in 2017, has helped save the life of a seven-year-old girl from Nashik in Maharashtra who was suffering from aplastic anaemia, a rare and serious blood disorder.

In a major breakthrough, a team of senior doctors from LOTUS Institute of Haematology, Oncology and Bone Marrow Transplantation, recently conducted Indias first dual cord blood transplant through an unrelated donor using Community Stem Cell Banking. People familiar with the development said the transplant was challenging because no apt bone marrow donors were available and the cost of retrieval of matching units from public cord blood banks would have been high.

The girls parents, as members of LifeCell Community Bank, placed a request for two matching cord blood units after the childs sibling was found to be only a 50% (4/8) match. Two high-quality matches (7/8) were found in the registry, which fulfilled the requirement for umbilical cord blood transplantation. The parents could withdraw the matched units at no extra expense, which would have cost around 45 lakh per unit.

Mayur Abhaya, MD, LifeCell International said, The purpose of Community Cord Blood Banking is to ensure easy and rapid access to stem cells for every Indian without the hurdles of public and private banking models. While stem cells from the umbilical cord blood can be procured from global public banks, the probability of finding a match for a patient of Indian origin is less than 10% because of the low inventory of available units plus the big issue of donor dropouts.

Mr. Abhaya said, Luckily, since the family was a part of LifeCells community banking programme, they could gain quick, free access to the huge inventory of over 50,000 qualified and consented units available at LifeCell, which provides greater than 97% probability of finding a match.

In majority of blood-related disorders treatable by transplants, patients own stem cells are not suitable. Hence, the best donor is a close family member, usually a sibling. However, in this case, there was only a 50% match with the sibling, thus needing a match from an unrelated donor, LifeCell said in a statement. It said while a regular stem cell transplant requires a dose of 25 million cells per kg of the patients weight, for aplastic anaemia, the recommended minimum dose is 40 million cells per kg, which is not easy to find.

The community banking model made it possible and the child received a timely transplant with an encouraging prognosis. Just 18 days after the transplant, white blood cells were completely engrafted, and platelets and red blood cell production also increased drastically, the statement added.

Dr. Pritesh Junagade, director, LOTUS Hospital, expressed surprise that the retrieval process for two cord blood units was smooth and at no additional cost to the patient as compared to other banking models.

Tasneem Bohari, the childs father, said: It was two years ago that my daughter was diagnosed with aplastic anaemia. At the time of diagnosis, the doctors had suggested she would need a stem cell transplant eventually and it would be the best possible treatment in the future.

The family did research and made enquiries about which stem cell bank to opt for as they were expecting their second child. It was during this time that their friends and relatives suggested LifeCell to them. Their doctor also suggested that they could go ahead and preserve their babys stem cell with LifeCell.

At the time of preservation, we didnt have much idea about Community Stem Cell Banking and its benefits, but today we are happy to associate with LifeCell, who have helped my daughter lead a quality life through cord blood transplant, Mr. Bohari said.

Community Cord Blood Banking allows sharing of preserved umbilical cord stem cells from a common pool amongst the members of the community. The model offers greater and easier access to donor stem cells, unlimited retrievals at the cost of one enrolment, and a higher probability for finding a close match for potentially life-saving treatments.

This facility ensures complete protection to the child, siblings, parents, and maternal and paternal grandparents from more than 80 disorders treatable by stem cells.

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Community Cord Blood Banking saves life of child with aplastic anaemia - The Hindu

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