Research offers a phylogenetic and ontogenetic overview of the primitive streak – News-Medical.net

In their publication in Science, Professor Guojun Sheng (Kumamoto University, Japan), Professor Alfonso Martinez Arias (Universidad Pompeu Fabra, Spain) and Professor Ann Sutherland (University of Virginia Health System, USA) offer a phylogenetic and ontogenetic overview of the primitive streak and its role in mediating amniote (vertebrate animals that develop on land) gastrulation, and discuss the implications of embryonic stem cell-based models of early mammalian embryogenesis on the function of this structure. Most animals are bilaterally symmetrical and are organized using two basic coordinate systems. The first gives cells spatial identities along the anteroposterior (head-to-tail) and dorsoventral (back-to-front) axes.

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New discoveries make steps toward lipoedema diagnosis and treatment – Mirage News

New research from St Vincents Institute of Medical Research (SVI) on lipoedema could support the development of new treatments and the development of a diagnostic screening test. Led by Dr Tara Karnezis and Associate Professor Ramin Shayan, the new study has identified a stem cell in lipoedema and a gene that drives excess fat growth elements key to diagnosing and treating the condition

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With its Parkinsons treatment, TreeFrog Therapeutics shows cell therapy is no longer science fiction – The Times Hub

December 6, 2021 It is certainly the revelation of the year 2021. As it celebrates its three years of existence at the end of the year, the start-up fromPessac (Gironde)TreeFrog Therapeutics will be at the heart of the discussions on Tuesday for the eighth editiondInnovaday. Organized by the start-up incubatorBordeaux Unitec, the event will indeed look back on the most resounding business successes of the year.

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Irving Weissman Laboratory | Institute for Stem Cell …

Research in the Weissman Lab Stem cell biology in health and disease and the development of macrophage-based immunotherapy: Tissue stem cells are rare and only make the maturing and mature cells of the tissue they serve [HSC for blood, CNS stem cells for brain, skeletal stem cells for bone and cartilage and bone marrow inductive microenvironments, etc.]. Within a tissue they are the only cells that can self-renew throughout life. While the usual outcome is tissue and organ homeostasis, stem cells can accumulate and propagate mutations over many years, and those mutant stem cells can contribute to disease.

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World AIDS Day: is a cure for HIV finally in sight? – Thomson Reuters Foundation

By Hugo Greenhalgh LONDON, Dec 1 (Thomson Reuters Foundation) - Andrew Caldwell laughs at the idea he is brave. But taking part in groundbreaking clinical trials of regenerative medicine, the 35-year-old American underwent a bone marrow transplant and a punishing course of chemotherapy - all part of a novel process that might yet provide a cure for HIV. "My goal was just being able to contribute towards the advancement of research for a cure in whatever capacity," said Caldwell, a San Francisco-based operations manager who was diagnosed with HIV eight years ago.

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New genetic technology for gene expression analysis of cancer cells – News-Medical.net

Please can you introduce yourself, tell us what inspired your recent research into gene expression signatures, cancer progression, and chemotherapy resistance? My name is Rong Lu. I am an assistant professor in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of the University of Southern California.

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Stem Cell Therapy Restores Insulin Production in Patients with Type 1 Diabetes – MD Magazine

A 64-year old man may have become the first person to be cured of type 1 diabetes (T1D), the result of a cell-infusion grown from stem cells similar to insulin-producing pancreas cells Back in June, Brian Shelton received the infusion in a clinical trial by Vertex Pharmaceuticals, Inc. They were testing a decade-in-the-making treatment started by a scientist, Doug Melton, PhD, Xander University Professor at Harvard and Investigator of the Howard Hughes Medical Institute, whose own family was impacted by the disease. Today, Sheltons body automatically controls insulin and blood sugar levels, representing a huge leap forward in the treatment of T1D.

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