Introduction Retinal degeneration is one of the major reasons for vision loss, and stem cell therapy has been extensively investigated to repair and regenerate damaged retinal cells. Several types of stem cells have been tested in preclinical and clinical trials to understand their efficiency in reversing retinal degeneration. To date, human embryonic stem cells (hESCs)-, induced pluripotent stem cells (iPSCs)-derived RPE cells, mesenchymal stem cells (MSCs) and retinal progenitor cells (RPCs) have been tested in addition to paracrine factors and exosomes derived from MSCs.
Stem cells have been the object of much excitement and controversy amongst both scientists and the general population. Surprisingly, though, not everybody understands the basic properties of stem cells, let alone the fact that there is more than one type of cell that falls within the stem cell category. Here, Ill lay out the basic concepts of stem cell biology as a background for understanding the stem cell research field, where it is headed, and the enormous promise it offers for regenerative medicine
Pluripotent stem cells are master cells. Theyre able to make cells from all three basic body layers, so they can potentially produce any cell or tissue the body needs to repair itself
As viable human brain tissue is not available for use in studying disease development and creating therapies for neurological disorders like Huntingtons disease (HD), researchers desperately needed an alternative cell source for this purpose.
Stem cell research holds great promise for biomedical sciencefrom helping us better understand how diseases develop and spread, to serving as accurate screens for new drugs, to developing cell-based therapies for diabetes, heart failure, Parkinsons disease, and many other conditions that affect millions of Americans. There are 2 basic types of human stem cells: embryonic stem (ES) cells and non-embryonic, or adult stem cells.
Members of Congress Object to Tax Dollars Funding Unethical Science U.S. Senator Roger Wicker, R-Miss., along with U.S. Representatives Blaine Luetkemeyer, R-Mo., and Vicky Hartzler, R-Mo., led Members of Congress in sending a letterto Health and Human Services (HHS) Secretary Xavier Becerra criticizing HHSs recent decisions to discontinue the National Institutes of Healths (NIH) nonpartisan Fetal Tissue Research Ethics Advisory Board (EAB) and to restore taxpayer funding for federal researchers to obtain, use, and store the body parts of aborted children.
The type of stem cell called iPSCs (induced Pluripotent Stem Cells) has worked its way into potential therapies for virtually every part of your body, and the research is being done in thousands of labs around the world. In the less than 15 years since Shinya Yamanaka created the first iPSCs this versatile type of stem cell has become a favorite candidate for creating tissues to repair or replace parts of our bodies that just arent working right
Pluripotent stem cells, including embryonic stem cells (ES cells) and induced pluripotent stem cells (iPSCs), have the capacity to give rise to differentiated progeny representative of all three germ layers (ectoderm, endoderm, and mesoderm). The ability to expand pluripotent cells in vitro and subject them to direct differentiation to produce specific cell types is crucial to the development of cell-based therapies to replace or restore tissue that has been damaged by disease or injury.
Scientists in Japan from fiscal 2023 will applytechnology to createinduced pluripotent stem (iPS) cells to solve the mystery of how people age, saidNobel laureate Shinya Yamanaka, urging the government to continue funding regenerative medicine research. Yamanaka,who was awarded the 2012 Nobel Prize in Physiology or Medicine jointly with Sir John B.