image:Engineered Drug Delivery of Mesenchymal Stromal Cell Therapy. (Left) IV infusion of MSCs is limited by low bioavailability. (Right) By incorporating MSCs into an ex vivo blood-contacting device, their bioavailability is enhanced and the release of immunomodulatory factors directly into the bloodstream can be controlled. view more
Credit: AlphaMed Press
Durham, NC Scientists are reporting promising results in the early stages of a clinical trial designed to gauge the feasibility of a new type of treatment for people with acute kidney disease. Released in STEM CELLS Translational Medicine, the study shows how mesenchymal stromal cells (MSCs) delivered using a new ex vivo drug delivery system SBI-101 can keep MSCs viable longer and reprogram the peripheral immune response toward organ repair.
Acute kidney disease occurs when a kidney is suddenly unable to do its job of filtering blood and allows dangerous levels of waste to accumulate. The most severe cases require dialysis or a kidney transplant. Unfortunately, dialysis-dependent acute kidney injury has a mortality rate as high as 50 to 70 percent.
Inflammation is a key driver behind this. In critical illnesses inflammation mediators become dysregulated, driving a cytokine storm leading to a vicious cycle of immunity that further damages the kidney and other organs. Current treatments fail to broadly address these underlying inflammatory processes.
Rebalancing the inflammatory response with a cell immunotherapy may offer a multifaceted approach to break the cycle and restore organ function after severe injury, explained the studys corresponding author, Biju Parekkadan, Ph.D., the scientific co-founder of Sentien Biotechnologies, Inc., in Lexington, Mass. Sentien executed its first-in-human study by working with several centers across the United States to test its SBI-101 product in a Phase 1b clinical trial.
MSCs secrete several types of molecules that modulate an immune cells response to inflammation and therefore have great potential for use in regenerative medicine. However, MSCs administered the conventional intravenous way are generally filtered out in the lungs and undetectable in the body soon after administration. Given this rapid clearance, they may not be able to match the dose needed to durably impact a systemic immune response, Dr. Parekkadan said.
This pharmacological insight has led to the search for a more efficient method of delivering MSCs. The innovation of SBI-101 therapy is the combination of off-the-shelf MSCs and an FDA-approved blood filtration device to improve and control the exposure to MSCs. This design allows for the patients blood to be reprogrammed outside the body, in a device housing MSCs, thereby maintaining their viability for the duration of treatment.
In effect, SBI-101 behaves as tissue of MSCs that works outside the body to sense inflammation in the patients bloodstream and respond with a natural mixture of growth factors, cytokines and chemokines to normalize immune signaling and function, Dr. Parekkadan explained.
The Phase 1 trial reported on in SCTM was designed to test the safety, tolerability and pharmacology of SBI-101 in adults with life-threatening kidney failure who were already receiving dialysis. Sixteen patients were recruited for the study. Twelve were treated with SBI-101, along with their standard continuous renal replacement therapy (CCRT) regimen, while four received a sham SBI-101 along with CRRT. The treatment period lasted for at least 12 hours, and up to 24. (CCRT is a slower form of dialysis that puts less stress on the heart. Treatment generally lasts 24 hours, versus the four hours of conventional dialysis routines.)
Assessments were then taken in intervals over a 28-day period after treatment. They showed that MSCs were viable for the 24-hour dose by measured secreted factor levels, verifying a longer duration of therapy than intravenous routes have shown. Moreover, SBI-101 promoted an immunotherapeutic response that was associated with a reduction in kidney injury by measuring surrogate biomarkers. No serious adverse effects related to SBI-101 were seen.
These early results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney. This important first step lays a foundation to study how this immunotherapy can impact patient outcomes in larger patient trials, Dr. Parekkadan concluded.
"This study highlights a potential clinical approach that could change the outcome for patients who suffer acute kidney injury and are dialysis dependent, said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and Director of the Wake Forest Institute for Regenerative Medicine. These clinical trial results highlight the healing potential of mesenchymal stem cells and warrant further study.
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The full article, Pharmacological Effects of Ex Vivo MSC Immunotherapy in Patients with Acute Kidney Injury and Underlying Systemic Inflammation, can be accessed at https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/sctm.21-0043.
About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), co-published by AlphaMed Press and Wiley, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. SCTM is the official journal partner of Regenerative Medicine Foundation.
About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS (http://www.StemCells.com), celebrating its 39th year, is the world's first journal devoted to this fast paced field of research. The Oncologist (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 26th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.
About Wiley: Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical and scholarly journals, combined with our digital learning, assessment and certification solutions, help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 200 years, we have delivered consistent performance to our stakeholders. The company's website can be accessed at http://www.wiley.com.
About Regenerative Medicine Foundation (RMF): The non-profit Regenerative Medicine Foundation fosters strategic collaborations to accelerate the development of regenerative medicine to improve health and deliver cures. RMF pursues its mission by producing its flagship World Stem Cell Summit, honouring leaders through the Stem Cell and Regenerative Medicine Action Awards, and promoting educational initiatives.
Stem Cells Translational Medicine
Randomized controlled/clinical trial
People
Pharmacological effects of ex vivo mesenchymal stem cell immunotherapy in patients with acute kidney injury and underlying systemic inflammation
28-Sep-2021
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