Explained: How Indias First-Ever Saviour-Sibling Born Through ART Saved Life Of Brother With Thalassemia – Swarajya

Indias first saviour sibling experiment is a success, reports The Hindu.

Previously, the blood cells from umbilical cord of a compatible sibling have been used to cure Thalassemia. However, this was the first time that a saviour-sibling was conceived through assisted reproductive techniques (ART) using pre-genetic diagnosis and screening test.

Kavya Solanki, the one-year old saviour sibling was conceived in-vitro by her parents to save her elder brother, Abhijeet, who was born with Thalassemia in November 2013.

When Abhijeet, unlike normal babies, did not achieve the growth milestones, the parents took him to doctors. The parents then learned that Abhijeet had Thalassemia major.

What is Thalassemia?

Thalassemia is a genetic disorder inherited from biological parents. In a Thalassemic person, certain genes responsible for the production of haemoglobin are missing, causing production of abnormal red blood cells. This results in a lack of oxygen in the bloodstream, rendering the patients anaemic.

The patients are also prone to suffer from other health problems like osteoporosis, heart and liver diseases, and infections.

Patients with severe Thalassemia require regular blood transfusions. The procedure usually takes 1 to 4 hours. Since red blood cells live only for about 120 days, one needs repeated transfusions to maintain a healthy supply of red blood cells.

According to Abhijeets parents, he required blood transfusion every 25 days and the duration between two transfusions decreased as he grew older. By the age of six Abhijeet had undergone 80 transfusions.

How does saviour sibling help?

An alternative treatment is blood and bone marrow transplant. Doctors opine that the the best therapeutic option for Thalassemia major patients is bone marrow transplant from an human leukocyte antigen (HLA)-identical donor. If the transplant is successful, the person starts producing healthy blood cells.

In Abhijeets case, his family members and older sister could not be the donor as their HLA did not match.

Abhijeets father Sahdev Singh Solankis research led them to the concept of saviour sibling. The family then sought out Manish Banker, medical director of Nova IVF Fertility in Ahmedabad.

Banker started the assisted reproductive therapy, called pre-implantation genetic testing, for monogenic disorder with HLA matching.

The couple underwent three cycles of in vitro fertilisation (test tube baby). The 18 embryos thus created were genetically examined to check whether they carry any diseases.

Only one perfectly matched Abhijeets HLA. The matching embryo was then implanted in Abhijeet's mother, Alpa Solanki, who delivered a baby girl a year ago.

The genetically engineered baby girl, Kavya, was free from the familys hereditary disease as well as transplant-compatible with his older brother.

However, Kavya had to grow up and weigh 10 kg before she could donate cord blood or hematopoietic stem cells for transplantation to save her critically ill sibling

Prior to the transplant, the patients receive special radiation (chemotherapy) and medicines to destroy the abnormal stem and temporarily suppress the immune system so that it wont reject the donor cells after the transplant.

After the transplant, the doctor checks blood counts every day to see if new blood cells have started to grow in the bone marrow.

Abhijeets transplant took place in March this year, and since, Abhijeet hasnt received blood transfusion, indicating that he is cured of Thalassemia. His haemoglobin count was reportedly 11.3.

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Explained: How Indias First-Ever Saviour-Sibling Born Through ART Saved Life Of Brother With Thalassemia - Swarajya