Long-term data show durable survival benefits with Opdivo (nivolumab) plus Yervoy, (ipilimumab), including five-year results in renal cell carcinoma and three-year results in malignant pleural mesothelioma
Phase 3 data from RELATIVITY-047 demonstrate prolonged benefit beyond initial treatment of the LAG-3 blocking antibody relatlimab and PD-1 inhibitor nivolumab fixed-dose combination for patients with previously untreated unresectable or metastatic melanoma
Updated pivotal Phase 3 data from CheckMate -577 reinforce the benefit of Opdivo in earlier stages of esophageal and gastroesophageal cancers
Bristol Myers Squibb (NYSE: BMY) today announced that data reinforcing the potential of immunotherapies to impact clinical outcomes for patients will be featured at the European Society for Medical Oncology (ESMO) 2021 Virtual Congress from September 16-21. Research demonstrating the durable, long-term benefits of Opdivo plus Yervoy in advanced or metastatic cancers, growing evidence supporting the use of Opdivo in earlier-stage cancers, and results for combinations with novel agents such as the investigational LAG-3 blocking antibody relatlimab will be presented among approximately 36 Bristol Myers Squibb-sponsored studies, investigator-sponsored studies and collaborations at the Congress.
Since immune checkpoint inhibitors were introduced more than a decade ago, they have played a transformational role in treating cancers with high unmet need, and most importantly, helping people with cancer live longer, said Samit Hirawat, M.D. , executive vice president, chief medical officer, Global Drug Development, Bristol Myers Squibb. Our data at this years ESMO show that Opdivo and Opdivo -based regimens, including combinations with our immune checkpoint inhibitor Yervoy and our third distinct immune checkpoint inhibitor relatlimab, have the potential to help advance the standard of care in both metastatic and earlier stages of cancer.
Key data being presented by Bristol Myers Squibb at ESMO 2021 include:
Summary of Presentations
*All times noted are Central European Summer Time (CEST)
Abstract Title
Author
Presentation
Type/#
Session Title
Session
Date/Time/Channel
Gastrointestinal
Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer (EC/GEJC) following neoadjuvant chemoradiotherapy (CRT): 14-month follow-up of CheckMate- 577
Dr. Markus Moehler
ePoster
#1381P
N/A
Thursday, September 16,
8:30 CEST
On-Demand
Nivolumab (NIVO) Plus Chemotherapy (Chemo) or Ipilimumab (IPI) vs Chemo as First-Line (1L) Treatment for Advanced Gastric Cancer/Gastroesophageal Junction Cancer/Esophageal Adenocarcinoma (GC/GEJC/EAC): CheckMate 649 Study
Dr. Yelena Janjigian
#LBA7
Presidential Symposium 2
Sunday, September 19,
16:12-16:27 CEST
Channel 1
Genitourinary
Conditional survival and 5-year follow-up in CheckMate 214: first-line nivolumab + ipilimumab (N+I) versus sunitinib (S) in advanced renal cell carcinoma (aRCC)
Dr. Robert Motzer
ePoster
#661P
N/A
Thursday, September 16,
8:30 CEST
On-Demand
First-line nivolumab + cabozantinib vs sunitinib in patients (pts) with advanced renal cell carcinoma (aRCC) in subgroups based on prior nephrectomy in the CheckMate 9ER trial
Dr. Camillo Porta
ePoster
#663P
N/A
Thursday, September 16,
8:30 CEST
On-Demand
CheckMate 9KD cohort A2 final analysis: nivolumab (NIVO) + rucaparib for chemotherapy (CT)-nave metastatic castration-resistant prostate cancer (mCRPC)
Dr. Daniel Petrylak
Mini-oral
#579MO
Mini Oral Session Genitourinary Tumours, Prostate
Sunday, September 19,
17:55-18:00 CEST
Channel 2
Head and Neck
Nivolumab (N) + ipilimumab (I) vs EXTREME as first-line (1L) treatment (tx) for recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Final results of CheckMate 651
Dr. Athanassios Argiris
Proffered Paper
#LBA36
Proffered Paper Session Head and Neck Cancer, Excl. Thyroid
Monday, September 20,
13:40-13:50 CEST
Channel 1
Lung
First-line nivolumab (NIVO) plus ipilimumab (IPI) vs chemotherapy (chemo) in patients with unresectable malignant pleural mesothelioma: 3-year update from CheckMate- 743
Dr. Solange Peters
Proferred Paper
#LBA65
Proffered Paper Session Non-Metastatic NSCLC and Other Thoracic Malignancies
Friday, September 17,
13:4013:50 CEST
Channel 2
RELATIVITY-104: first-line relatlimab (RELA) + nivolumab (NIVO) with chemotherapy vs. NIVO with chemotherapy in stage IV or recurrent non-small cell lung cancer (NSCLC) a phase 2, randomized, double-blind study
Dr. Daniel Morgensztern
ePoster
#1359TiP
N/A
Thursday, September 16,
8:30 CEST
On-Demand
Melanoma
Relatlimab (RELA) + nivolumab (NIVO) vs. NIVO in previously untreated metastatic or unresectable melanoma: additional efficacy in RELATIVITY-047
Dr. Stephen Hodi
Oral
#1036O
Proffered Paper Session Melanoma and Other Skin Tumours
Saturday, September 18,
13:30-14:50 CEST Channel 4
CheckMate 204: 3-year outcomes of treatment with combination nivolumab (NIVO) plus ipilimumab (IPI) for patients (pts) with active melanoma brain metastases (MBM)
Dr. Hussein Tawbi
Mini-oral
#1039MO
Mini Oral Session Melanoma and Other Skin Tumours
Monday, September 20,
17:35-17:40 CEST Channel 2
Early Development
A phase 2 randomized study of BMS-986012, an antifucosyl-GM1 monoclonal antibody, plus carboplatin, etoposide, and nivolumab (NIVO) as first-line (1L) therapy in patients with extensive-stage small cell lung cancer (ES-SCLC)
Dr. Quincy Chu
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