An immune-boosting protein called interleukin 7 (IL-7) in combination with radiation has shown evidence that it could be considered as a replacement for temozolomide, especially among the nearly 70% of patients who have a type of tumour that does not respond well to this chemotherapy. In a recently published paper in Clinical Cancer Research, researchers explain that current immunotherapies, immune checkpoint inhibitors, work by taking the brakes off immune cells that are already present
A new therapy showed improvement over the standard treatment for relapsed B-cell lymphoma, according to a study published in the New England Journal of Medicine. The results suggest a new path forward for patients with relapsed large B-cell lymphoma, according to Leo Gordon, MD, the Abby and John Friend Professor of Cancer Research and a co-author of the study. "This finding might herald a shift in the paradigm of how we treat patients with large B-cell lymphoma," said Gordon, who is also a professor of Medicine in the Division of Hematology and Oncology and a member of the Robert H.
image:Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration view more Credit: The Buck Institute for Research on Aging Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the tau interactome uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons. They also suggest a mechanism for how tau gets released from neurons and spreads throughout the brain, a pathological process that is strongly correlated with disease progression
The IL-6 family of proteins has a bad reputation: it can promote inflammation, arthritis, autoimmune disease and even cancer. However, a new USC-led study published in Communications Biology reveals the importance of IL-6 and associated genes for maintaining and regenerating cartilage in both the joints and in the growth plates that enable skeletal growth in children. We show, for the first time, that the IL-6 family, previously almost exclusively associated in the musculoskeletal field with arthritis, bone and muscle loss, and other chronic inflammatory diseases, is required for the maintenance of skeletal stem and progenitor cells, and for the healthy growth and function of the joints and spine, said the studys corresponding author Denis Evseenko, who is the J.
The IL-6 family of proteins has a bad reputation: it can promote inflammation, arthritis, autoimmune disease and even cancer.
A key breakthrough came in the early 2000s, when Japanese researchers hit on a simple formula to turn any type of tissue into powerful stem cells, similar to ones in an embryo. Imaginations ran wild. Scientists realized they could potentially manufacture limitless supplies of nearly any type of cellsay, nerves or heart muscle
Work type: Full-timeDepartment: School of Biomedical Sciences (22600)Categories: Academic-related Staff Applications are invited for appointment as Post-doctoral Fellow in Cancer Immunology & Stem Cell Engineering of the School of Biomedical Sciences (Ref.: 511522), to commence as soon as possible for one year, with the possibility of renewal. Applicants should have a Ph.D
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Simple Summary: Certain types of cancer have higher relapse rates compared to others, and cancer stem cells (CSCs) have been shown as the main drivers of cancer relapse and cancer severity. This subpopulation of cells displays stem-like characteristics which bolster tumorigenesis along with metastasis and lead to poorer prognoses. Autophagy has been studied as a mechanism by which CSCs maintain stemness and acquire resistance to chemotherapy and radiation.
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