Testing times: Snorkels, zinc, cord blood and probiotics trialled in COVID-19 fight – The Age

Inspired by Italian doctors who turned full-face snorkels into crude oxygen masks during the peak of Italys COVID-19 crisis, Dr Joosten bought 120 snorkels from Melbournes camping shops.

Dr Joosten thinks his masks may present a cheap and effective way of safely transferring patients in hospitals.Credit:Dr Simon Joosten

Using a 3D-printed connecter, they can be hooked up to oxygen tanks. When a patient breathes in, room air is sucked into the mask. When they breathe out, a valve filters the air for any virus.

Australian hospitals never ran out of oxygen masks, but Dr Joosten hopes the invention may be helpful for moving potentially infectious patients through hospitals.

At the moment, doctors strap a breathing mask to a patient's face, and then put an N95 mask on top a fair solution but one that does not guarantee the patient will not spread the virus. The doctors transporting them need to wear full protective gear, and everywhere the patient travels needs to be cleaned.

"The transfers arent dangerous, but they take a lot of effort," Dr Joosten said.

He thinks his snorkels may present a cheaper and more effective alternative. His study to test that theory, which is fully funded, is awaiting approval from Monash Medical Centre.

Several eyebrow-raising clinical trials have been launched by Australian scientists.

One plans to give probiotics to nurses to see if that reduces their COVID-19-related stress. Another will try to treat COVID-19 using stem cells taken from umbilical cord blood.

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A third will test regular sprays of antibiotics in the nose to try to kill the virus that causes COVID-19. A fourth trial will try high-dose zinc injected straight into COVID-19 patients.

Some science leaders fear having all these separate trials is a warning sign.

"The diversity of approaches is fascinating," said Professor Gemma Figtree, president of the Australian Cardiovascular Alliance. "But what this also highlights is the need for co-ordination, collaboration and strategic leadership that overarches all that.

"You cannot rely only on excellence if you want to develop a vaccine for COVID. If you were going to build a rocket to Mars, you would not rely entirely on highly competitive grants."

While innovative, scientists say the diversity of approaches to tacking COVID-19 is indicative of a wider problem: the lack of a co-ordinated national research strategy.

Get our Coronavirus Update newsletter for the day's crucial developments at a glance, the numbers you need to know and what our readers are saying. Sign up to The Sydney Morning Herald's newsletter here and The Age's here.

Liam is The Age and Sydney Morning Herald's science reporter

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Global trade impact of the Coronavirus Hematopoietic Stem Cell Transplantation (HSCT) Market Shares, Strategies and Forecast Worldwide, 2019-2027 -…

A recent market study on the global Hematopoietic Stem Cell Transplantation (HSCT) market reveals that the global Hematopoietic Stem Cell Transplantation (HSCT) market is expected to reach a value of ~US$ XX by the end of 2029 growing at a CAGR of ~XX% during the forecast period (2019-2029). The impact of the COVID-19 pandemic on the global Hematopoietic Stem Cell Transplantation (HSCT) market is discussed in the presented study.

The Hematopoietic Stem Cell Transplantation (HSCT) market study encloses a thorough analysis of the overall competitive landscape and the company profiles of leading market players involved in the global Hematopoietic Stem Cell Transplantation (HSCT) market. Further, the presented study offers accurate insights pertaining to the different segments of the global Hematopoietic Stem Cell Transplantation (HSCT) market such as the market share, value, revenue, and more.

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The following doubts are addressed in the market report:

Key Highlights of the Hematopoietic Stem Cell Transplantation (HSCT) Market Report

The presented report segregates the Hematopoietic Stem Cell Transplantation (HSCT) market into different segments to ensure the readers gain a complete understanding of the different aspects of the Hematopoietic Stem Cell Transplantation (HSCT) market.

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Segmentation of the Hematopoietic Stem Cell Transplantation (HSCT) market

Competitive Outlook

This section of the report throws light on the recent mergers, collaborations, partnerships, and research and development activities within the Hematopoietic Stem Cell Transplantation (HSCT) market on a global scale. Further, a detailed assessment of the pricing, marketing, and product development strategies adopted by leading market players is included in the Hematopoietic Stem Cell Transplantation (HSCT) market report.

Companies Mentioned in the Report

The report profiles key manufacturers in the hematopoietic stem cell transplantation (HSCT) Market based on various attributes such as company details, SWOT analysis, strategic overview, financials, and business overview. Major players profiled in this report include Regen Biopharma, Inc., Escape Therapeutics, Inc., Lonza Group Ltd., and Pluristem Therapeutics Inc.

The global hematopoietic stem cell transplantation (HSCT) Market has been segmented as follows:

By Transplant Type

By Disease Indication

By Application

By Region

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Global trade impact of the Coronavirus Hematopoietic Stem Cell Transplantation (HSCT) Market Shares, Strategies and Forecast Worldwide, 2019-2027 -...

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Cover Corona Outbreak: Hematopoietic Stem Cells HSCs Market Is Set To Experience Revolutionary Growth By 2025 Cole Reports – Cole of Duty

Hematopoietic Stem Cells HSCs MarketLatest Research Report 2020:

The Hematopoietic Stem Cells HSCs report provides an independent information about the Hematopoietic Stem Cells HSCs industry supported by extensive research on factors such as industry segments size & trends, inhibitors, dynamics, drivers, opportunities & challenges, environment & policy, cost overview, porters five force analysis, and key companies

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In this report, our team offers a thorough investigation of Hematopoietic Stem Cells HSCs Market, SWOT examination of the most prominent players right now. Alongside an industrial chain, market measurements regarding revenue, sales, value, capacity, regional market examination, section insightful information, and market forecast are offered in the full investigation, and so forth.

Scope of Hematopoietic Stem Cells HSCs Market: Products in the Hematopoietic Stem Cells HSCs classification furnish clients with assets to get ready for tests, tests, and evaluations.

Major Company Profiles Covered in This Report

Kite Pharma Inc., Thermo Fisher Scientific, PromoCell, CellGenix Technologie Transfer GmbH, Cesca Therapeutics Inc., R&D Systems, Genlantis, Lonza Group Ltd., TiGenix N.V., ScienCell Research Laboratories, China Cord Blood Corporation, Vcanbio, Boyalife, Beike Biotechnology,

Hematopoietic Stem Cells HSCs Market Report Covers the Following Segments:<

Market segment by Type, the product can be split into

Leukocyte, Lymphocytes, Red Blood Cells, Platelets,

Market segment by Application, split into

Blood System Diseases, Autoimmune Diseases, Others,

Market segment by Regions/Countries, this report covers

North America (United States, Canada and Mexico)

Europe (Germany, UK, France, Italy, Russia and Turkey etc.)

Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)

South America (Brazil etc.)

Middle East and Africa (Egypt and GCC Countries)

North America

Europe

Asia-Pacific

South America

Center East and Africa

United States, Canada and Mexico

Germany, France, UK, Russia and Italy

China, Japan, Korea, India and Southeast Asia

Brazil, Argentina, Colombia

Saudi Arabia, UAE, Egypt, Nigeria and South Africa

Market Overview:The report begins with this section where product overview and highlights of product and application segments of the global Hematopoietic Stem Cells HSCs Market are provided. Highlights of the segmentation study include price, revenue, sales, sales growth rate, and market share by product.

Competition by Company:Here, the competition in the Worldwide Hematopoietic Stem Cells HSCs Market is analyzed, By price, revenue, sales, and market share by company, market rate, competitive situations Landscape, and latest trends, merger, expansion, acquisition, and market shares of top companies.

Company Profiles and Sales Data:As the name suggests, this section gives the sales data of key players of the global Hematopoietic Stem Cells HSCs Market as well as some useful information on their business. It talks about the gross margin, price, revenue, products, and their specifications, type, applications, competitors, manufacturing base, and the main business of key players operating in the global Hematopoietic Stem Cells HSCs Market.

Market Status and Outlook by Region:In this section, the report discusses about gross margin, sales, revenue, production, market share, CAGR, and market size by region. Here, the global Hematopoietic Stem Cells HSCs Market is deeply analyzed on the basis of regions and countries such as North America, Europe, China, India, Japan, and the MEA.

Application or End User:This section of the research study shows how different end-user/application segments contribute to the global Hematopoietic Stem Cells HSCs Market.

Market Forecast:Here, the report offers a complete forecast of the global Hematopoietic Stem Cells HSCs Market by product, application, and region. It also offers global sales and revenue forecast for all years of the forecast period.

Research Findings and Conclusion:This is one of the last sections of the report where the findings of the analysts and the conclusion of the research study are provided.

About Us:

We publish market research reports & business insights produced by highly qualified and experienced industry analysts. Our research reports are available in a wide range of industry verticals including aviation, food & beverage, healthcare, ICT, Construction, Chemicals and lot more. Brand Essence Market Research report will be best fit for senior executives, business development managers, marketing managers, consultants, CEOs, CIOs, COOs, and Directors, governments, agencies, organizations and Ph.D. Students.

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Stem Cell Umbilical Cord Blood Market 2020 Share Insights and Dynamics | Cells for Life, Cryolife, Cryo-Cell Cole Reports – Cole of Duty

Futuristic Reports, The growth and development of Global Stem Cell Umbilical Cord Blood Market Report 2020 by Players, Regions, Type, and Application, forecast to 2026 provides industry analysis and forecast from 2020-2026. Global Stem Cell Umbilical Cord Blood Market analysis delivers important insights and provides a competitive and useful advantage to the pursuers. Stem Cell Umbilical Cord Blood processes, economic growth is analyzed as well. The data chart is also backed up by using statistical tools.

Simultaneously, we classify different Stem Cell Umbilical Cord Blood markets based on their definitions. Downstream consumers and upstream materials scrutiny are also carried out. Each segment includes an in-depth explanation of the factors that are useful to drive and restrain it.

Key Players Mentioned in the study are Cell Care, Cells for Life, Cryolife, Cryo-Cell, CBR (Cord Blood Registry), Stemlife, CELLTREE(CELLTREE), StemOne Biologicals, Healthbanks Biotech, Stemcyte Inc, Smart Cells, ViaCord, LifeCell, Cryosite, Cordlife

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Key Issues Addressed by Stem Cell Umbilical Cord Blood Market: It is very significant to have Stem Cell Umbilical Cord Blood segmentation analysis to figure out the essential factors of growth and development of the market in a particular sector. The Stem Cell Umbilical Cord Blood report offers well summarized and reliable information about every segment of growth, development, production, demand, types, application of the specific product which will be useful for players to focus and highlight on.

Businesses Segmentation of Stem Cell Umbilical Cord Blood Market:

On the basis on the applications, this report focuses on the status and Stem Cell Umbilical Cord Blood outlook for major applications/end users, sales volume, and growth rate for each application, including-

Blood Disorders Cancers Immune Disorders Metabolic Disorders Others

On the basis of types/products, this Stem Cell Umbilical Cord Blood report displays the revenue (Million USD), product price, market share, and growth rate of each type, split into-

Allogeneic stem cell umbilical cord blood Autologous stem cell cord blood

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NOTE: Our team is studying Covid-19 impact analysis on various industry verticals and Country Level impact for a better analysis of markets and industries. The 2020 latest edition of this report is entitled to provide additional commentary on latest scenario, economic slowdown and COVID-19 impact on overall industry. Further it will also provide qualitative information about when industry could come back on track and what possible measures industry players are taking to deal with current situation.

OR

You just drop an Email to: [emailprotected] us if you are looking for any Economical shift towards the New Normal on any Country or Industry Verticals.

Stem Cell Umbilical Cord Blood Market Regional Analysis Includes:

Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) North America (the United States, Mexico, and Canada.) South America (Brazil etc.) The Middle East and Africa (GCC Countries and Egypt.)

Stem Cell Umbilical Cord Blood Insights that Study is going to provide:

Gain perceptive study of this current Stem Cell Umbilical Cord Blood sector and also possess a comprehension of the industry; Describe the Stem Cell Umbilical Cord Blood advancements, key issues, and methods to moderate the advancement threats; Competitors In this chapter, leading players are studied with respect to their company profile, product portfolio, capacity, price, cost, and revenue. A separate chapter on Stem Cell Umbilical Cord Blood market structure to gain insights on Leaders confrontational towards market [Merger and Acquisition / Recent Investment and Key Developments] Patent Analysis** Number of patents filed in recent years.

Table of Content:

Global Stem Cell Umbilical Cord Blood Market Size, Status and Forecast 20261. Market Introduction and Market Overview2. Industry Chain Analysis3. Stem Cell Umbilical Cord Blood Market, by Type4. Stem Cell Umbilical Cord Blood Market, by Application5. Production, Value ($) by Regions6. Production, Consumption, Export, Import by Regions (2016-2020)7. Market Status and SWOT Analysis by Regions (Sales Point)8. Competitive Landscape9. Analysis and Forecast by Type and Application10. Channel Analysis11. New Project Feasibility Analysis12. Market Forecast 2020-202613. Conclusion

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Resilience Hope and Being a Survivor – Curetoday.com

When I first heard the word "resilience" I did not really understand what it meant, I was listening to a presentation about a third world mission trip and about how people survive their hardships there. But now, I personally understand the meaning and am ready to share my journey.

When my husband was diagnosed with cancer, I understood what may be ahead, since I am a nurse with many years of experience. The first two years of his journey were stressful, but we had each other, enjoyed our life and worked through the decisions and experience. The turning point was when he his cancer returned, and he started radiation therapy. Then, we hit what felt like a big wall.

I was diagnosed with breast cancer.

I remember sharing this news with him and he stated, "I am stronger than you think" and he proved that to be so true over the next 3 years.

Our journey together is a story of resilience, sharing hope and caring for each other. His cancer involved traveling over 3 hours to a medical center for surgery, needing an artificial airway and nutrition via a feeding tube. We spent our time together going to the local cancer center on separate days for each of our own chemotherapy treatments. As a nurse, I cared for him even during my own radiation treatment period and still kept working at my job as much as possible.

During that time, I kept thinking, is this what it takes to have that resilience? Is resilience what it takes to keep caring, maintaining hope and surviving a day at a time. If you look up the word, " resilience", there are terms like hardiness, strength and toughness. However, I have learned that it means much more.

The experience of a cancer journey together is more than what those words convey. I would often say to myself, " I am stronger than I thought too" not realizing I was beginning to understand resilience. When looking inward, you begin to understand the human spirit and what we face in life cannot truly be explained to others, but only matures every day with every hurdle we tackle and overcome.

I am a widow now and a cancer survivor, who looks back on that time in our lives, with joy of being together, with pride at how we both endured and how much stronger we became because of it. Hope was always in front of us, leading us through each day.

You should never lose hope, because that optimism is what builds the courage that leads to learning what resilience really means.

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Pregnant and positive | Scientists look for COVID-19 immunity in the womb – WHAS11.com

PENNSYLVANIA, USA Brianna Boriosi, 30, and her husband Marc both are considered essential employees because they work in inpatient drug and alcohol treatment services. They are now self-quarantining at home because they both tested positive for COVID-19.

What makes their case more complicated and worrisome is that Brianna is 7-and-a-half months pregnant, due June 24. Of course she immediately called her doctors.

They told me I was their first positive pregnancy case with COVID-19 in their practice, Brianna said.

Almost immediately after she found out she was positive she was getting calls from the Pennsylvania Department of Health.They wanted to know what the circumstances were leading up to getting infected, but also they hoped Brianna would give consent for test samples.

Once the babys born, they talked about maybe taking some of the umbilical cord or the blood in there, Brianna said. As well as the placenta, and if Im willing, looking into possibly donating stem cells.

It didnt take long for her to say yes.

There was a possibility that the baby will either be immune or have some of these antibodies.

While doctors believe the virus will not get passed onto her unborn child, scientists hope what they find through tests can help them to get to a vaccine and the cure.

Anything I can do to help or donate or whatever, Im definitely all about it.

Her positive test could lead to keeping everyone negative for the virus in the future. Brianna wants that for their baby as well as their two-year-old son.

Because both Brianna and Marc are positive, doctors presume their son is as well. The couple is thankful that he hasnt shown any symptoms, and they hope and pray it stays that way.

RELATED: Feds to track, publicly share info on nursing home COVID-19 outbreaks

RELATED: Rise in accidental poisonings coincides with coronavirus lockdowns

RELATED: Reports suggest many may have had coronavirus with no symptoms

Contact reporter John Charlton atjcharlton@whas11.com. Follow him onTwitter (@JCharltonNews) andFacebook.

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Pregnant and positive | Scientists look for COVID-19 immunity in the womb - WHAS11.com

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Growing Awareness about of Stem Cells Cryopreservation Equipments Market Expected to Grow with High CAGR During Forecast Period 2020-2029 – Science…

Documenting the Industry Development of Stem Cells Cryopreservation Equipments Market concentrating on the industry that holds a massive market share 2020 both concerning volume and value With top countries data, Manufacturers, Suppliers, In-depth research on market dynamics, export research report and forecast to 2029

As per the report, the Stem Cells Cryopreservation Equipments Market is anticipated to gain substantial returns while registering a profitable annual growth rate during the predicted time period.The global stem cells cryopreservation equipments market research report takes a chapter-wise approach in explaining the dynamics and trends in the stem cells cryopreservation equipments industry.The report also provides the industry growth with CAGR in the forecast to 2029.

A deep analysis of microeconomic and macroeconomic factors affecting the growth of the market are also discussed in this report. The report includes information related to On-going demand and supply forecast. It gives a wide stage offering numerous open doors for different businesses, firms, associations, and start-ups and also contains authenticate estimations to grow universally by contending among themselves and giving better and agreeable administrations to the clients. In-depth future innovations of stem cells cryopreservation equipments Market with SWOT analysis on the basis Of type, application, region to understand the Strength, Weaknesses, Opportunities, and threats in front of the businesses.

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***[Note: Our Complimentary Sample Report Accommodate a Brief Introduction To The Synopsis, TOC, List of Tables and Figures, Competitive Landscape and Geographic Segmentation, Innovation and Future Developments Based on Research Methodology are also Included]

An Evaluation of the Stem Cells Cryopreservation Equipments Market:

The report is a detailed competitive outlook including the Stem Cells Cryopreservation Equipments Market updates, future growth, business prospects, forthcoming developments and future investments by forecast to 2029. The region-wise analysis of stem cells cryopreservation equipments market is done in the report that covers revenue, volume, size, value, and such valuable data. The report mentions a brief overview of the manufacturer base of this industry, which is comprised of companies such as- Charter, Worthington Industries, Cesca Therapeutics, Shengjie Cryogenic Equipment, Sichuan mountain vertical, Qingdao Beol.

Segmentation Overview:

Product Type Segmentation :

Liquid phase,Vapor phase

Application Segmentation :

Cord Blood Stem Cells Cryopreservation,Stem Cells Cryopreservation

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Key Highlights of the Stem Cells Cryopreservation Equipments Market:

The fundamental details related to Stem Cells Cryopreservation Equipments industry like the product definition, product segmentation, price, a variety of statements, demand and supply statistics are covered in this article.

The comprehensive study of stem cells cryopreservation equipments market based on development opportunities, growth restraining factors and the probability of investment will anticipate the market growth.

The study of emerging Stem Cells Cryopreservation Equipments market segments and the existing market segments will help the readers in preparing the marketing strategies.

The study presents major market drivers that will augment the stem cells cryopreservation equipments market commercialization landscape.

The study performs a complete analysis of these propellers that will impact the profit matrix of this industry positively.

The study exhibits information about the pivotal challenges restraining market expansion

The market review for the global market is done in context to region, share, and size.

The important tactics of top players in the market.

Other points comprised in the Stem Cells Cryopreservation Equipments report are driving factors, limiting factors, new upcoming opportunities, encountered challenges, technological advancements, flourishing segments, and major trends of the market.

Check Table of Contents of This Report @ https://market.us/report/stem-cells-cryopreservation-equipments-market/#toc

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Cord Stem Cell Banking Market (COVID -19 Impact Analysis) : Emerging Trends, Business Opportunities and Segmentation. Major Players are Cryo-Save AG,…

The Cord Stem Cell Banking Market report offers a complete and intelligent analysis of the competition, segmentation, dynamics, and geographical advancement of the global Cord Stem Cell Banking market. The market report is sure to lend a hand in enhancing sales and improving return on investment (ROI). This market research report provides clients with the supreme level of market data and information which is specific to their niche and their business requirements. This global Cord Stem Cell Banking market research report is a proven source to gain valuable market insights and take better decisions about the important business strategies.

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Global Cord stem cell banking market is estimated to reach USD 13.8 billion by 2026 registering a healthy CAGR of 22.4%. The increasing number of parents storing their childs cord blood, acceptance of stem cell therapeutics, high applicability of stem cells are key driver to the market.

Few of the major market competitors currently working in the globalcord stem cell banking marketareCBR Systems, Inc., Cordlife, Cells4Life Group LLP, Cryo-Cell International, Inc., Cryo-Save AG, Lifecell, StemCyte India Therapeutics Pvt. Ltd, Viacord, SMART CELLS PLUS., Cryoviva India, Global Cord Blood Corporation, National Cord Blood Program, Vita 34, ReeLabs Pvt. Ltd., Regrow Biosciences Pvt. Ltd. , ACROBiosystems., Americord Registry LLC., New York Blood Center, Maze Cord Blood, GoodCell., AABB, Stem Cell Cryobank, New England Cryogenic Center, Inc. among others

Market Definition: Global Cord Stem Cell Banking Market

Cord stem cells banking is nothing but the storing of the cord blood cell contained in the umbilical cord and placenta of a newborn child. This cord blood contains the stem cells which can be used in future to treat disease such as leukemia, thalassemia, autoimmune diseases, and inherited metabolic disorders, and few others.

Segmentation: Global Cord Stem Cell Banking Market

Cord Stem Cell banking Market : By Storage Type

Cord Stem Cell banking Market : By Product Type

Cord Stem Cell banking Market : By Service Type

Cord Stem Cell banking Market : By Indication

Cord Stem Cell banking Market : By Source

Cord Stem Cell banking Market : By Geography

Browse Detailed TOC, Tables, Figures, Charts and Companies @https://www.databridgemarketresearch.com/toc?dbmr=global-cord-stem-cell-banking-market&raksh

Key Developments in the Cord Stem Cell banking Market:

Cord Stem Cell banking Market : Drivers

Cord Stem Cell banking Market : Restraint

Competitive Analysis: Global Cord Stem Cell Banking Market

Global cord stem cell banking market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions and others to increase their footprints in this market. The report includes market shares of cord stem cell banking market for Global, Europe, North America, Asia Pacific, South America and Middle East & Africa.

Scope of the Cord Stem Cell banking Market Report :

The report shields the development activities in the Cord Stem Cell banking Market which includes the status of marketing channels available, and an analysis of the regional export and import. It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments. This will benefit the reports users, that evaluates their position in Cord Stem Cell banking market as well as create effective strategies in the near future.

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She was on a tropical vacation when she received a text message: You need to come home to save a life – The Philadelphia Inquirer

At first, it didnt hit Stewart that her donation would help save someones life the potential recipient, unknown to her, was too abstract. But then she thought of her father, a nurse in Reading, and how, years ago, when he was 48, she was just 8. She let herself feel what it would have been like to lose him back then.

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She was on a tropical vacation when she received a text message: You need to come home to save a life - The Philadelphia Inquirer

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Cord blood – Wikipedia

Blood in the placenta and umbilical cord after birth

Cord blood (umbilical cord blood) is blood that remains in the placenta and in the attached umbilical cord after childbirth. Cord blood is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders.

Cord blood is composed of all the elements found in whole blood - red blood cells, white blood cells, plasma, platelets.[1] Compared to whole blood some differences in the blood composition exist, for example, cord blood contains higher numbers of natural killer cells, lower absolute number of T-cells and a higher proportion of immature T-cells.[2] However, the interest in cord blood is mostly driven by the observation that cord blood also contains various types of stem and progenitor cells, mostly hematopoietic stem cells.[1][2][3] Some non-hematopoietic stem cell types are also present in cord blood, for example, mesenchymal stem cells, however these are present in much lower numbers that can be found in adult bone marrow.[2][3]Endothelial progenitor cells and multipotent unrestricted adult stem cells can also be found in cord blood.[3] The stem cells found in cord blood are often confused with embryonic stem cells - unlike embryonic stem cells, cord blood stem cells are all types of adult stem cells, are lineage restricted and are not pluripotent.[3][4][5]

Cord blood is used the same way that hematopoietic stem cell transplantation is used to reconstitute bone marrow following radiation treatment for various blood cancers, and for various forms of anemia.[6][7] Its efficacy is similar as well.[6]

Adverse effects are similar to hematopoietic stem cell transplantation, namely graft-versus-host disease if the cord blood is from a genetically different person, and the risk of severe infection while the immune system is reconstituted.[6] To assure that the smallest amount of complications occur during transplantation, levels of engraftment must be present; specifically both neutrophils and platelets must be being produced.[8] This process of neutrophil and platelet production after the transplant, however, takes much longer than that of stem cells.[8] In many cases, the engraftment time depends on the cell dose, or the amount of stem cells obtained in the sample of blood.[8] In Dr. Moises article about umbilical cord blood [9] (as cited in [8]), it was found that there is approximately 10% less stem cells in cord blood than there is in bone marrow. Therefore a sufficient amount of cord blood must be obtained in order to collect an adequate cell dose, however this amount varies from infant to infant and is irreplaceable. Given that this idea is quite new, there is still a lot of research that needs to be completed. For example, it is still unknown how long cord blood can safely be frozen without losing its beneficial effects.[8]

There is a lower incidence with cord blood compared with traditional HSCT, despite less stringent HLA match requirements.[6]

Umbilical cord blood is the blood left over in the placenta and in the umbilical cord after the birth of the baby. There are several methods for collecting cord blood. The method most commonly used in clinical practice is the "closed technique", which is similar to standard blood collection techniques. With this method, the technician cannulates the vein of the severed umbilical cord using a needle that is connected to a blood bag, and cord blood flows through the needle into the bag. On average, the closed technique enables collection of about 75 ml of cord blood.[10]

Collected cord blood is cryopreserved and then stored in a cord blood bank for future transplantation. Cord blood collection is typically depleted of red blood cells before cryopreservation to ensure high rates of stem cell recovery.[11]

The first successful cord blood transplant (CBT) was done in 1988 in a child with Fanconi anemia.[6] Early efforts to use CBT in adults led to mortality rates of about 50%, due somewhat to the procedure being done in very sick people, but perhaps also due to slow development of immune cells from the transplant.[6] By 2013, 30,000 CBT procedures had been performed and banks held about 600,000 units of cord blood.[7]

The AABB has generated accreditation standards for cord blood banking facilities.[12]

In the United States, the Food and Drug Administration regulates any facility that stores cord blood; cord blood intended for use in the person from whom it came is not regulated, but cord blood for use in others is regulated as a drug and as a biologic.[13] Several states also have regulations for cord blood banks.[12]

In Europe, Canada, and Australia use of cord blood is regulated as well.[12] In the United Kingdom the NHS Cord Blood Bank was set up in 1996 to collect, process, store and supply cord blood; it is a public cord blood bank and part of the NHS.[14]

A cord blood bank may be private (i.e. the blood is stored for and the costs paid by donor families) or public (i.e. stored and made available for use by unrelated donors). While public cord blood banking is widely supported, private cord banking is controversial in both the medical and parenting community. Although umbilical cord blood is well-recognized to be useful for treating hematopoietic and genetic disorders, some controversy surrounds the collection and storage of umbilical cord blood by private banks for the baby's use. Only a small percentage of babies (estimated at between 1 in 1,000 to 1 in 200,000[15]) ever use the umbilical cord blood that is stored. The American Academy of Pediatrics 2007 Policy Statement on Cord Blood Banking stated: "Physicians should be aware of the unsubstantiated claims of private cord blood banks made to future parents that promise to insure infants or family members against serious illnesses in the future by use of the stem cells contained in cord blood." and "private storage of cord blood as 'biological insurance' is unwise" unless there is a family member with a current or potential need to undergo a stem cell transplantation.[15][16] The American Academy of Pediatrics also notes that the odds of using a person's own cord blood is 1 in 200,000 while the Institute of Medicine says that only 14 such procedures have ever been performed.[17]

Private storage of one's own cord blood is unlawful in Italy and France, and it is also discouraged in some other European countries. The American Medical Association states "Private banking should be considered in the unusual circumstance when there exists a family predisposition to a condition in which umbilical cord stem cells are therapeutically indicated. However, because of its cost, limited likelihood of use, and inaccessibility to others, private banking should not be recommended to low-risk families."[18] The American Society for Blood and Marrow Transplantation and the American Congress of Obstetricians and Gynecologists also encourage public cord banking and discourage private cord blood banking. Nearly all cord blood transplantations come from public banks, rather than private banks,[16][19] partly because most treatable conditions can't use a person's own cord blood.[15][20] The World Marrow Donor Association and European Group on Ethics in Science and New Technologies states "The possibility of using ones own cord blood stem cells for regenerative medicine is currently purely hypothetical....It is therefore highly hypothetical that cord blood cells kept for autologous use will be of any value in the future" and "the legitimacy of commercial cord blood banks for autologous use should be questioned as they sell a service which has presently no real use regarding therapeutic options."[21]

The American Academy of Pediatrics supports efforts to provide information about the potential benefits and limitations of cord blood banking and transplantation so that parents can make an informed decision. In addition, the American College of Obstetricians and Gynecologists recommends that if a patient requests information on umbilical cord blood banking, balanced information should be given. Cord blood education is also supported by legislators at the federal and state levels. In 2005, the National Academy of Sciences published an Institute of Medicine (IoM) report titled "Establishing a National Cord Blood Stem Cell Bank Program".[22]

In March 2004, the European Union Group on Ethics (EGE) has issued Opinion No.19[23] titled Ethical Aspects of Umbilical Cord Blood Banking. The EGE concluded that "[t]he legitimacy of commercial cord blood banks for autologous use should be questioned as they sell a service, which has presently, no real use regarding therapeutic options. Thus they promise more than they can deliver. The activities of such banks raise serious ethical criticisms."[23]

Though uses of cord blood beyond blood and immunological disorders is speculative, some research has been done in other areas.[24] Any such potential beyond blood and immunological uses is limited by the fact that cord cells are hematopoietic stem cells (which can differentiate only into blood cells), and not pluripotent stem cells (such as embryonic stem cells, which can differentiate into any type of tissue). Cord blood has been studied as a treatment for diabetes.[25] However, apart from blood disorders, the use of cord blood for other diseases is not in routine clinical use and remains a major challenge for the stem cell community.[24][25]

Along with cord blood, Wharton's jelly and the cord lining have been explored as sources for mesenchymal stem cells (MSC),[26] and as of 2015 had been studied in vitro, in animal models, and in early stage clinical trials for cardiovascular diseases,[27] as well as neurological deficits, liver diseases, immune system diseases, diabetes, lung injury, kidney injury, and leukemia.[28]

Cord blood is being used to get stem cells with which to test in people with type 1 diabetes mellitus.[29]

The stem cells from umbilical cord blood are also being used in the treatment of a number of blood diseases including blood cancers.[30]

Cord blood is also being studied as a substitute for normal blood transfusions in the developing world.[30][31] More research is necessary prior to the generalized utilization of cord blood transfusion.[30]

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