A team of South Dakota State University chemistry researchers uncovered how cancer cells utilize a simple sugar residue to disguise themselves from the immune system. What they learned will help scientists develop more effective cancer therapeutics.
"We utilized the lens of organic chemistry to understand how cancer cells evade the immune system," explained assistant chemistry and biochemistry professor Dr. Rachel Willand-Charnley. The project is part of her chemical biology research program, which uses various fields of chemistry to solve biological problems. Willand-Charnley's research has applications in biotechnology and biomedicine.
Willand-Charnley, doctoral students Mathias Anim and Albert Armoo and Susan Grabenstein Roh, a biochemistry major who received her bachelor's degree in May, analyzed what is known as the Sialic acid-Siglec receptor pathway. They examined the pathway in colon and lung cancer cells using CRISPR-Cas9 gene-edited cell lines to determine how the cancer cells evade detection using sugars on their cell surface.
The results are published in the June issue of Glycobiology, a peer-reviewed Oxford Academic research journal. Roh, who at the time was a biochemistry major, is a shared first author on the article. The project was supported by the Willand-Charnley laboratory's startup funding for new faculty members.
Willand-Charnley came to SDSU in 2018 after completing postdoctoral research under the tutelage of renowned chemistry professor Carolyn Bertozzi at the University of California, Berkeley, and then at Stanford University. Her research combines expertise in organic chemistry, glycobiology and cancer immunology.
Cells are literally decorated with sugar residues, known as glycans. Cancers also have a sugar coat. How do sugars, like Sialic acid, allow cancers to participate in 'immune evasion'? The immune system is programmed to identify cellular abnormalities, including deviations in the sugar coat, and mark them for degradation, but the question is why are certain cancer cells not being killed by the immune system?"
Dr. Rachel Willand-Charnley, assistant chemistry and biochemistry professor
The paper focuses on how cancers use simple sugar residues, which she described as a sugary costume, to mimic healthy cells, thereby evading the immune system. "This research will allow scientists to build better therapeutics that cleave off the sugars, essentially removing the cancer cells' sugary costume," Willand-Charnley said. "It will open avenues for more targeted, effective cancer therapeutics related to glycans."
Both doctoral students see the benefits of this unique approach to improving cancer therapeutics. "It was really intriguing to realize that a single genetic modification could actually make cancers resistant to immunotherapy, make them invisible to the immune system," said Anim, who is from Ashiaman, Ghana. He earned his bachelor's and master's degrees in biochemistry at Kwame Nkrumah University of Science and Technology in Kumasi Ashanti, Ghana.
Armoo, who is from Tema, Ghana, said, "For me, it was interesting finding out that a coat of sugar plays a role in resistance to chemotherapeutics. It's not always a drug metabolite, but also the patients' own immune system being able to identify the cancer cells." He began doctoral work at SDSU after earning his undergraduate degree at the University of Bradford in the United Kingdom and a master's degree from the University of Bradford's Institute of Cancer Therapeutics.
Roh, a Mitchell, South Dakota, native, began working on the project as a sophomore. "I wanted to work with genetics, so when Dr. Willand-Charnley talked about cell lines with gene knockouts the first day in my organic chemistry class, that piqued my interest in doing research with her group," Roh said. "I was the first person to sign on (to the project)."
Willand-Charnley said, "Undergraduates (in my lab) are treated like graduate students. My expectation is that they will run their research like a graduate student."
Roh continued, "I found my own papers relating to the topic, read through them and explained why I felt they were relevant and what I learned from them (during the weekly group meetings)." Every three weeks, it was her turn to present her findings to the group-;in a professional fashion. In 2019, Roh received the American Chemical Society award for best undergraduate research poster.
Even though Roh was the only undergraduate student working on the project, she said, "I had a lot of responsibility. I was able to be shared first author on the paper because I put in equal amount of the work-;that's what it took."
In addition to doing research part time during the school year, she also spent two summers working full time on the project. Roh, who is now a graduate research assistant in the Department of Biology and Microbiology, feels prepared for graduate school, thanks to her experiences in Willand-Charnley's lab.
In addition to running successful research programs, Willand-Charnley also focuses on diversity and outreach. "One of my goals as a scientist is to increase diversity in the STEM sciences," Willand-Charnley said. However, "as students traverse academia and get older, we tend to have less diversity, why? One school of thought is that the STEM sciences are seen as intimidating. Thus, how do we fix this?"
Willand-Charley is working on launching an outreach program for kindergarten through fifth graders. "I want to elicit interest in the STEM sciences from a very young age. What better way to garner interest and show that science is fun than hands-on demonstrations with scientists in the classroom?"
Grabenstein, S., et al. (2021) Deacetylated sialic acids modulates immune mediated cytotoxicity via the sialic acid-Siglec pathway. Glycobiology. doi.org/10.1093/glycob/cwab068.
Read the rest here:
- Humanigen Announces Peer-Reviewed Publication in The Journal of Medical Economics Demonstrating the Clinical and Economic Benefits of Lenzilumab -... - January 19th, 2022
- What the World's First Pig to Human Heart Transplant Could Mean for the Future of Transplants - Technology Networks - January 19th, 2022
- The natural, and medicinal, bounties of Lotus Stem (Nadru) - Kashmir Reader - January 19th, 2022
- Benefits of including Giloy to your diet and guide to use it - Newsd.in - January 16th, 2022
- Dr. Khera and Dr. Pearlman discuss innovations in testosterone therapy - Urology Times - January 13th, 2022
- NIH researchers develop first stem cell model of albinism to study related eye conditions - National Institutes of Health - January 13th, 2022
- A UVM Researcher Uses Artificial Intelligence and Frog Cells to Create Self-Replicating 'Xenobots' - Seven Days - January 13th, 2022
- Type 1 Diabetes and Sleep: What You Can Do About It - Healthline - January 13th, 2022
- Can You Fight Aging? Scientists Are Testing Drugs to Help - The Wall Street Journal - January 13th, 2022
- What's autophagy? It's the ultimate detox that doesn't yet live up to the hype - The Conversation AU - January 13th, 2022
- CAR-T cell therapy with ASCT brings hope to lymphoma patients - Chinadaily USA - January 11th, 2022
- Umbilical cord blood donations offer hope for those in Japan in need of stem cells - The Japan Times - January 11th, 2022
- Fate Therapeutics Announces FDA Clearance for FT536, a First-in-class MICA/B-targeted CAR NK Cell Product Candidate for the Treatment of Solid Tumors... - January 11th, 2022
- Hyperbaric oxygen therapy saved Minnesota man from amputation - The Dickinson Press - January 11th, 2022
- The State of Diabetes Care, 100 Years After the First Insulin Shot - Healthline - January 11th, 2022
- Equillium Announces Multiple Abstracts Accepted for Presentation at the Transplantation & Cellular Meetings of ASTCT and CIBMTR - Business Wire - January 11th, 2022
- Orchard Therapeutics Announces Recent Commercial and Regulatory Progress for Late-stage HSC ... - The Bakersfield Californian - January 11th, 2022
- Cancer Stem Cells Market Overview by Industry Dynamics, Regional Analysis and Forecast 2021 to 2026 Industrial IT - Industrial IT - January 2nd, 2022
- How to reverse your bio age like Tom Brady and Jeff Bezos in 8 weeks - New York Post - January 2nd, 2022
- Pros and Cons of Stem Cell Research Debate: Benefits ... - December 29th, 2021
- Skincare treatments that will dominate 2022 - Times of India - December 29th, 2021
- With soaring demand for meat, it's time to fund animal-free protein research | TheHill - The Hill - December 29th, 2021
- How do some people live past 100 years? Studying rare mutations may crack the scientific mystery - Scroll.in - December 29th, 2021
- The future of Food? From 3D-printed meat-free steaks to edible insect burgers - nation.lk - The Nation Newspaper - December 29th, 2021
- Nonsteroidal Joint Injection Options The Horse - TheHorse.com - December 26th, 2021
- Innovative Methods Legendary Athletes Have Used to Remain the Best - 24/7 Wall St. - December 25th, 2021
- Pork or beef? Stem cells pave the way for lab-grown meat - SYFY WIRE - December 23rd, 2021
- Systemic Mastocytosis Treatments Gain Hope Due To Increasing Novel Treatment Options - PRNewswire - December 23rd, 2021
- MESO NUMISMATICS, INC. Management's Discussion and Analysis of Financial Condition and Results of Operations (form 10-Q) - marketscreener.com - December 23rd, 2021
- Scientists Used CRISPR Gene Editing to Choose the Sex of Mouse Pups - Singularity Hub - December 23rd, 2021
- What Is Sodium Hyaluronate and How Can It Benefit the Skin? - InStyle - December 23rd, 2021
- Which Tea is the Healthiest? The Benefits of the Most Popular - The Beet - December 19th, 2021
- Viagra associated with reduced risk of Alzheimer's disease - National Institutes of Health - December 19th, 2021
- BMS and Kite Unveil CAR-T Successes in Lymphoma - BioSpace - December 19th, 2021
- Magenta Therapeutics Highlights Presentations of Data Related to Stem Cell Mobilization and Targeted Conditioning at the 2021 American Society of... - December 19th, 2021
- 6 Uses and Benefits of CBD On Skin - City Watch - December 19th, 2021
- Sangamo Therapeutics Announces Updated Preliminary SAR445136 Phase 1/2 Proof-of-Concept Data Showing Tole - Benzinga - December 12th, 2021
- Politicians Push For Late-Term Abortion Laws to Increase Profits of the Industry's Black Baby Parts Business - BlackNews.com - December 11th, 2021
- Affimed to Host Virtual Investor Call Today to Discuss Treatment of CD30-positive Lymphoma ... - The Bakersfield Californian - December 11th, 2021
- Using algae to make cell-based seabass fillets: 'We anticipate that cultured fish can have increased health benefits' - FoodNavigator.com - December 11th, 2021
- Regenerative Medical Center for Stem Cell Treatments MSC+ ... - December 11th, 2021
- Global Stem Cell Partnering Terms and Agreements 2021 Report - Featuring Regenetech, Stempeutics and Arthrex Among Others - ResearchAndMarkets.com -... - December 9th, 2021
- Benefits of Pulsed Laser-based Skin Therapy - Newswise - December 9th, 2021
- What is orthobiologics? - Sanford Health News - December 9th, 2021
- Two year follow up shows delaying umbilical cord clamping saves babies lives - News - The University of Sydney - December 9th, 2021
- PharmaEssentia's BESREMi (ropeginterferon alfa-2b-njft) Now Available for the Treatment of People With Polycythemia Vera in the United States -... - December 7th, 2021
- Awards and Honors: Winter 2021 | Department of Medicine News | Stanford Medicine - Stanford Medicine - December 7th, 2021
- Here's Why Longeveron Is Surging Today - Motley Fool - December 4th, 2021
- Global Regenerative Medicine Partnering Report/Directory 2021: Terms and Agreements for 1600 Deals 2014-2 - Benzinga - December 4th, 2021
- CAR T-Cell Therapy Market is anticipated to reach US$ 2.8 Bn by 2031 - PRNewswire - December 4th, 2021
- Stem-cell implant prototypes pave the way towards life-long treatment for type 1 diabetes - ZME Science - December 3rd, 2021
- Certain Patients With Heart Failure May Benefit From Stem Cell Therapy - Pharmacy Times - December 3rd, 2021
- Humanigen Announces Conference Call and Webcast to Discuss Lancet Respiratory Medicine Publications and Provide a Corporate Update - Yahoo Finance - December 3rd, 2021
- Roundtable Discussion: Usmani and Participants Review Using Transplant and Combination Therapy in a Patient With Newly Diagnosed Multiple Myeloma -... - December 3rd, 2021
- Hematopoiesis and innate immunity: an inseparable couple for good and bad times, bound together by an hormetic relationship - DocWire News - December 3rd, 2021
- Reality of universal cancer prevention & cure - BSA bureau - December 3rd, 2021
- World Aids Day Improving the lives of everyone affected by HIV - QMUL - December 3rd, 2021
- Seres Therapeutics Announces First Patient Enrolled in Phase 1b Study of SER-155, an Investigational Microbiome Therapeutic to Reduce the Risk of... - December 3rd, 2021
- AVROBIO Presents Clinician Experience with FAB-GT Clinical Trial and Updated Safety Data for Investigational Gene Therapies in Fabry Disease and... - November 28th, 2021
- The questions surgical robots still need to answer - Becker's Orthopedic & Spine - November 24th, 2021
- Holiday Gift Guide 2021: The Best Wellness And Self-Care Essentials For Travel - Forbes - November 24th, 2021
- Investigating pathogens and their life cycles, for the benefit of society - MIT News - November 24th, 2021
- Mitigating Toxicities Will Position BCMA for Role in Triple-Class Refractory Multiple Myeloma - OncLive - November 24th, 2021
- Human Primary Cells Market 2021 | Know the Latest COVID19 Impact Analysis and Strategies of Key Players: Lonza, Thermo Fisher Scientific,... - November 21st, 2021
- Researcher Works for Diversity, Inclusion in Sciences, One Journal at a Time - Lab Manager Magazine - November 18th, 2021
- Raw Marijuana Won't Get You Stoned, But It Does Have Some Interesting Benefits - Benzinga - Benzinga - November 16th, 2021
- The 18 Best New November 2021 Skin-Care Launches That Deserve a Spot in Your Routine - Allure - November 16th, 2021
- Singapore Aims To Lead The World In Lab-Grown Meat - Intelligent Living - November 16th, 2021
- Dermarolling Your Scalp Is Proven to Increase Hair Growth and Thickness Here's How to Do It - Yahoo Lifestyle - November 15th, 2021
- Stem Cell Therapy for Heart Failure Reduces CV Events, Death in Select Patientsbut not Hospitalization - AJMC.com Managed Markets Network - November 15th, 2021
- JASPER THERAPEUTICS, INC. Management's Discussion and Analysis of Financial Condition and Results of Operations (form 10-Q) - marketscreener.com - November 15th, 2021
- Week In Review: Zai Lab Announces Two In-Licensings With Total Value Of $800 Million - Seeking Alpha - November 15th, 2021
- Beam gets green light to begin first clinical test of base editing - BioPharma Dive - November 15th, 2021
- GlycoMimetics GMI-1359 Data Selected for Presentation at 63rd American Society of Hematology (ASH) Annual Meeting and Exposition - Galveston County... - November 15th, 2021
- Jasper Therapeutics to Present at the Credit Suisse 30th Annual Virtual Healthcare Conference - GlobeNewswire - November 11th, 2021
- Biotech Companies are Expanding the Frontiers of Engineered Cell Therapy - BioSpace - November 11th, 2021
- Fate Therapeutics Announces Abstract Highlighting FT538 and - GlobeNewswire - November 11th, 2021
- Poseida Therapeutics to Present Preclinical Data Highlighting Fully Allogeneic CAR-T Product Candidates at the Society for Immunotherapy of Cancer... - November 11th, 2021
- Affimed Reports Third Quarter 2021 Financial Results and Highlights Operational Progress - KULR-TV - November 11th, 2021
- Jasper Therapeutics to Present at the Credit Suisse 30th Annual Virtual Healthcare Conference - Yahoo Finance - November 9th, 2021