ReproCELL Incorporated : Everything you need to know about the REPROCELL iPSC Biobank – marketscreener.com

Most neurodegenerative diseases do not have satisfying treatment options or a defined cause. And while more research is needed to develop novel therapies for these diseases, CNS drugs have lofty failure rates, both preclinically and clinically. Human CNS tissues are impossible to access from living subjects, and animal models lack clinical relevance.

However, human neurons derived from induced pluripotent stem cells (iPSCs) are more accessible than fresh tissues, more translational than animal models, and can be used in both pathological research and neurological drug screening. If you're a neurodegenerative disease researcher, the REPROCELL iPSC biobank was designed with you in mind. Established in 2020, this bank is built on a solid foundation of stem cell and biorepository expertise, granting you access to the most robust cells for neuronal differentiation. Here, we summarize the background behind the biobank's establishment and answer the most frequently asked questions about this offering.

Browse the full range of StemRNA Human iPSCs here

By establishing an iPSC biobank for neurodegenerative diseases, our iPSC Biobank makes it easier for CNS researchers to access clinically relevant disease models. We can ever perform neuronal differentiation as a complimentary service if you cannot complete this in-house.

As a researcher, you know that collecting good-quality data is critical to translatability. With this in mind, we wanted to offer a solid set of control lines in our biobank, procuring tissue from eight healthy donors of various races, sexes, and ages. Deriving iPSCs from a range of tissue sources and recruiting individuals that were aged 45 or older was a priority for us, as neurodegenerative diseases tend to affect adults in this age group.

Donor

SK001

SK002

SK003

BL003

SK004

SK005

SK006

iPSC 8023G

iPSC 7713G

Race

Asian-Indian

Asian-Indian

Asian-Indian

Asian-Indian

Asian-Indian

Caucasian

Filipino

Hispanic

Caucasian

Sex

Male

Female

Female

Female

Male

Male

Male

Female

Male

Age (years)

56

58

20

20

65

56

30

30

32

Tissue collected

Skin punch biopsy

Skin punch biopsy

Skin punch biopsy

EPC whole blood

Skin punch biopsy

Skin punch biopsy

Skin punch biopsy

EPC whole blood

EPC whole blood

Ability to recontact?

yes

yes

yes

yes

yes

yes

yes

no

no

Parkinson's is a genetically heterogeneous disease, so we wanted to offer a range of iPSCs carrying different PD mutations. In our current iPSC biobank, we have cells from donors with sporadic PD (SK007) and familial PD (SK008, SK010). Our biobank also includes two ALS donors carrying familial mutations in the FUS and TDP-43 genes (SK009, SK011), and we have an iPSC line from a patient with familial Alzheimer's Disease (AD) with a mutation in the PSN1 gene (SK012).

Donor

SK007 (PD)

SK008 (PD)

SK009 (ALS)

SK010 (PD)

SK011 (ALS)

SK012 (AD)

Race

Caucasian

Caucasian

African-American

Caucasian

Caucasian

Caucasian

Sex

Male

Female

Female

Female

Male

Male

Age (years)

56

58

20

20

65

56

Tissue collected

All Skin punch biopsy

Mutation

Ability to recontact?

yes

N/A

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ReproCELL Incorporated : Everything you need to know about the REPROCELL iPSC Biobank - marketscreener.com