Real-world analysis of patient characteristics, treatment outcomes, and healthcare resource utilization across Europe in patients with newly diagnosed…

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Leuk Lymphoma. 2021 Jun 14:1-10. doi: 10.1080/10428194.2021.1924369. Online ahead of print.

ABSTRACT

We aimed to compare real-world outcomes, resource use, and costs for patients with newly diagnosed multiple myeloma (NDMM) treated with continuous first-line (1 L) lenalidomide or fixed bortezomib in Europe. We performed a multicenter, retrospective, observational chart review of transplant-ineligible NDMM patients across 7 countries. Of 453 eligible patients, 220 received 1 L lenalidomide-based regimens; 105 (47.7%) received second-line (2 L) treatment, of which 50 (47.6%) received 2 L bortezomib. 233 patients received 1 L bortezomib-based regimens; 142 (60.9%) had 2 L treatment, of which 104 (73.2%) received 2 L lenalidomide. Patients receiving 1 L lenalidomide-based regimens had better progression-free survival than patients receiving 1 L bortezomib-based regimens (p = .002) and a longer time to 2 L or third-line treatment (both p < .05). Total treatment-associated monthly costs for patients receiving 1 L lenalidomide-based regimens (n = 171, 2,268.55) were significantly greater than for 1 L bortezomib-based regimens (n = 188, 1,724.77) (p < .001) over the follow-up period (median, 38.7 months).

PMID:34121589 | DOI:10.1080/10428194.2021.1924369

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Real-world analysis of patient characteristics, treatment outcomes, and healthcare resource utilization across Europe in patients with newly diagnosed...