Share This Article:A stem cell research center at UC Davis. Courtesy California Institute for Regenerative MedicineBy Barbara Feder Ostrov | CalMatters
For the second time in 16 years, California voters will decide the fate of the states multi-billion dollar stem cell research program that established the state as a worldwide leader.
Support Times of San Diego's growthwith a small monthly contribution
How the times have changed.
In November, as the pandemic drags on, Proposition 14 asks voters to spend nearly $8 billion to continue the program during a period when the research environment has significantly evolved and coronavirus has battered the states budget.
Thebond measurewould approve $5.5 billion in bonds to keep the states stem cell research agency running and grants flowing to California universities and companies.
At least $1.5 billion would be earmarked for brain and central nervous system diseases like Alzheimers and Parkinsons. The overall cost of the bonds and their interest totals about $7.8 billion,according tothe state legislative analyst. The state would pay about $260 million annually for 30 years, or about 1 percent of Californias annual budget.
Proposition 14 is essentially a repeat with a bigger price tag and a few tweaks ofProposition 71, which California voters approved in 2004 after then-President George W. Bush prohibited, on religious grounds, all federal funding of any stem cell research using human embryos.
The institute has nearly used up its original funding, so Prop. 71s author, real estate investor and attorney Robert N. Klein II, led a new effort to get Prop. 14 on the November ballot. That groundbreaking measure authorized $3 billion in state bonds to create the states stem cell research agency, the California Institute for Regenerative Medicine, and fund grants for research into treatments for Alzheimers disease, cancer, spinal cord injuries and other diseases.
This time, embryonic stem cell research is in a much different place, with federal funding no longer blocked and more funding from the biotech industry.
Voters will want to consider what Californias previous investment in stem cell research has accomplished. Its a nuanced track record.
While many scientific experts agree that Prop 71 was a bold social innovation that successfully bolstered emerging stem cell research, some critics argue that the institutes grantmaking was plagued by conflicts of interest and did not live up to the promises of miracle cures that Prop. 71s supporters made years ago. Although the agency is funded with state money, its overseen by its own board and not by the California governor or lawmakers.
The agency had done a very good job of setting priorities for stem cell research, including research using human embryos, and doling out $300 million annually to build up California as a regenerative medicine powerhouse, according to a 2013evaluationby the National Academies of Science, Engineering and Medicine.
But the report also found that because the institutes board is made up of scientists from universities and biotech firms likely to apply for grants, board members had almost unavoidable conflicts of interest.
Because human stem cells can develop into many types of cells, including blood, brain, nerve and muscle cells, scientists have long looked to them for potential treatments for currently incurable diseases and injuries. Researchers use two types of stem cells: embryonic stem cells, derived from unused human embryos created through in vitro fertilization, and adult stem cells, which are harder to work with but in some cases can be coaxed in a lab into behaving more like embryonic stem cells.
From the start, stem cell research has beenethically charged and politically controversialbecause human embryos are destroyed in some types of studies. Federal restrictions on the research have waxed and waned, depending on which political party holds power. While former President Bush restricted federal money for embryonic stem cell research, former President Obama removed those restrictions.
The Trump administration hasrestrictedgovernment research involving fetal tissue but not embryonic stem cells. However, anti-abortion lawmakershave called onthe President to once again end federal funding for embryonic stem cell research.
California-funded research has led to onestem cell treatmentfor a form of Severe Combined Immunodeficiency known as the bubble baby disease. Children with the rare disease dont make enough of a key enzyme needed for a normal immune system. Without treatment, they can die from the disease if not kept in a protective environment. The U.S. Food and Drug Administration is now reviewing the treatment but has not yet approved it for widespread use.
Although many of the agencys early grants were for basic science, the institute also has supported 64 clinical trials of treatments for many types of cancer, sickle cell disease, spinal cord injuries, diabetes, kidney disease and amyotrophic lateral sclerosis, commonlyknown as Lou Gehrigs disease.
A June 2020analysisby University of Southern California health policy researchers estimated that taxpayers initial $3 billion investment in the research institute helped create more than 50,000 jobs and generated $10 billion for the states economy.
Gov. Gavin Newsom has endorsed Proposition 14, and other supporters include the Regents of the University of California, the California Democratic Party, the Juvenile Diabetes Research Foundation, patient advocacy groups like the March of Dimes, and some local politicians and chambers of commerce.
Supporters have raisedmore than $8.5 million, including about $2 million from billionaire Dagmar Dolby, to pass the measure, according to California Secretary of State campaign finance reports.
The passage of Proposition 71 helped save my life, Sandra Dillon, a blood cancer patient, wrote in a San Diego Union-Tribunecommentarysupporting Proposition 14. She wrote that she had benefited from a drug developed with Institute-funded research that has beendesignatedby the FDA as a breakthrough therapy.
It is unimaginable to think that Californians would vote to discontinue this amazing effort I dont know where I would be or what condition I would be in if it wasnt for the investment Californians made nearly two decades ago.
Lawrence Goldstein, a UC San Diego professor of cellular and molecular medicine and stem cell researcher, said the grants were instrumental in furthering his research on treatments for Alzheimers disease and that Prop. 14 will help create new jobs. The agency has funded a great deal of very important stem cell medical research thats already produced terrific results and has the prospect of saving many more lives in the decade to come, he said.
Opponents include one member of the institutes board and a nonprofit that advocates for privacy in genetic research. They contend that the proposition seeks too much money and does not sufficiently address the conflicts of interest that cropped up after Prop. 71 was passed. They also note that private funding, including venture capital, for stem cell research has grown in recent years. Opponents had raised only $250 by late September, from a single contribution by theCalifornia Pro Life Council.
The editorial boards of some of Californias biggest newspapers also have opposed the measure, including theLos Angeles Times, theOrange County Register, theSan Francisco Chronicleand theSan Jose Mercury News/East Bay Times. TheFresno Bee,Modesto Bee, andSan Luis Obispo Tribunenewspaper editorial boards support Prop 14.
Jeff Sheehy, the only institute board member not to support Proposition 14, told CalMatters that the research environment has changed since voters initially approved state funding for stem cell research in 2004 and that California should prioritize other needs like education, health care, and housing.
I think the agencys done good work, but this was never planned to be funded forever with debt, Sheehy said. At this point the state cant afford it; were looking at a huge deficit.
CalMattersis a public interest journalism venture committed to explaining how Californias state Capitol works and why it matters.
Proposition 14 Aims to Keep California at Worldwide Center of Stem Cell Research was last modified: October 18th, 2020 by Editor
>> Subscribe to Times of San Diegos free daily email newsletter! Click here
See the original post:
- Stem Cell Scientists Explore the Latent Regenerative Potential of the Inner Ear - SciTechDaily - July 31st, 2021
- Colin Jackson health: Im in constant pain Athlete to undergo stem cell therapy to help - Express - July 31st, 2021
- The Talking Man: New Advances In Regenerative Medicine - Forbes - July 31st, 2021
- Medipost's clinical trial approved to evaluate efficacy of knee osteoarthritis treatment - Aju Business Daily - July 31st, 2021
- A Phase II Study of Polatuzumab Vedotin with Rituximab, Ifosfamide, Carboplatin, and Etoposide Before Stem Cell Transplantation in People with... - July 31st, 2021
- Background should not be a barrier to access stem cell transplant treatment and care - PoliticsHome - July 31st, 2021
- Treatment Approaches for Patients With R/R DLBCL - Targeted Oncology - July 31st, 2021
- Global $57.4 Billion Cell And Gene Therapy Manufacturing Market to 2028 - Rising Pressure on Drug Developers/Manufacturers to Meet the Growing Market... - July 31st, 2021
- Acute Myeloid Leukemia Fungal Infections: Types and Treatment - Healthline - July 31st, 2021
- Overview of DLBCL - Targeted Oncology - July 31st, 2021
- Roundtable Discussion: Participants Evaluate the Use of Transplant and MRD in Newly Diagnosed Multiple Myeloma - Targeted Oncology - July 31st, 2021
- Hematopoietic Stem Cell Transplantation (HSCT) Market: Allogeneic transplant is projected to continue to hold a dominant market share - BioSpace - July 27th, 2021
- Researchers develop a cell culture test to detect substances that harm the placenta and embryo - News-Medical.net - July 27th, 2021
- FDA Approves KEYTRUDA (pembrolizumab) for Treatment of Patients With High-Risk Early-Stage Triple-Negative Breast Cancer in Combination With... - July 27th, 2021
- Cryopreservation of Unrelated Donor SCTs Safe, Effective in Patients Who Underwent HSCT - Hematology Advisor - July 27th, 2021
- Combination drug therapy can significantly benefit patients with newly diagnosed blood cancer - The Institute of Cancer Research, London - The... - July 25th, 2021
- Study proposes repurposed drug to treat COVID-19 - The Hindu - July 25th, 2021
- Injecting mice with pulmonary endothelial cells can reverse symptoms of emphysema - News-Medical.Net - July 25th, 2021
- FDA gives speedy review to Bayer's Parkinson's stem cell therapy - - pharmaphorum - July 23rd, 2021
- Stemming the tide of stem-cell treatment scams - Houston Chronicle - July 23rd, 2021
- Regenerative Medicine provides new hope and healing - Summit Daily News - July 23rd, 2021
- Emphysema Reversed in Mice Given Injection of Healthy Pulmonary Endothelial Cells - Genetic Engineering & Biotechnology News - July 23rd, 2021
- Nelson: Gimpy girls have different means of recovery - Watertown Public Opinion - July 23rd, 2021
- Gene Therapy Protects Optic Nerve Cells and Vision in Mice with Retinal Injury and Glaucoma - Genetic Engineering & Biotechnology News - July 23rd, 2021
- Has COVID-19 Opened up the Route to Market for Cell and Gene Therapy? - Pharmaceutical Executive - July 23rd, 2021
- Transplant-Associated Thrombotic Microangiopathy: New Insights, Emerging Treatments - OncLive - July 23rd, 2021
- Bluebird, with little fanfare, is first to bring a second gene therapy to market - BioPharma Dive - July 23rd, 2021
- Belumosudil Granted Full Approval for Treatment of Chronic GVHD by FDA - Cancer Network - July 21st, 2021
- Creative Medical Technology Holdings Announces MyeloCelz The Company's Second Regenerative Immunotherapy Product - PRNewswire - July 21st, 2021
- Stem Cell Therapy Gets Fast Track Status for Parkinson Disease - Monthly Prescribing Reference - July 21st, 2021
- Stem cell model reveals how COVID-19 can infect the brain - Study Finds - July 21st, 2021
- Donating a chance at life: Kokomo teacher donates stem cells to 75-year-old woman through Be the Match - Kokomo Perspective - July 21st, 2021
- Young Patients With Multiple Myeloma May Benefit From Tandem Autologous Hematopoietic Stem Cell Transplantation - Hematology Advisor - July 21st, 2021
- Emerging Quadruplets, Novel Targets, and Immunotherapy Advances Personalized Medicine in Multiple Myeloma - OncLive - July 21st, 2021
- BlueRock Therapeutics Receives FDA Fast Track Designation for DA01 in the Treatment of Advanced Parkinson's Disease - Yahoo Finance - July 21st, 2021
- YOUR HEALTH: Finding cures by tracking cells - WQAD.com - July 21st, 2021
- Study shows promise of combining radiation therapy with dendritic-cell vaccines for breast cancer - News-Medical.Net - July 21st, 2021
- Profilin 1 Protein and Its Implications for Cancers - Cancer Network - July 17th, 2021
- Developmental Interest in Allogeneic PlacentaDerived Cell Therapies Expands - OncLive - July 17th, 2021
- For Patients with HIV and Cancer, a Multidisciplinary Treatment Approach is Critical - Targeted Oncology - July 17th, 2021
- Times really up! FDA authority to crack down on regenerative medicines upheld as grace period ends - JD Supra - July 15th, 2021
- The Memphis Institute of Regenerative Medicine Rebrands To Reflect Statewide Reach - UTHSC News - July 15th, 2021
- Dr. Sperling on Future Research With CAR T-Cell Therapy in Multiple Myeloma - OncLive - July 15th, 2021
- TiTAN-1 Trial of GEN-011 Initiates Treatment in Patients With Solid Tumors - Targeted Oncology - July 15th, 2021
- Saving a life, fixing the world - The Jewish Standard - July 15th, 2021
- Exosome spray may be better able to heal damaged hearts - New Atlas - July 15th, 2021
- Prime Medicine uncloaks with $315M to push 'search and replace' gene editing treatments - FierceBiotech - July 13th, 2021
- Dr. Sallman on Unmet Treatment Needs in Higher-Risk MDS - OncLive - July 13th, 2021
- U.S. Stem Cell, Inc The New Generation Company In The ... - July 11th, 2021
- Stem Cell Therapy - Stemedix | Regenerative Medicine Also ... - July 11th, 2021
- FIRM, CAS further cooperate to advance reproductive medicine research_china.org.cn - China.org.cn - July 11th, 2021
- England's drug price watchdog rejects Orchard's groundbreaking gene therapy after first round of talks - FiercePharma - July 11th, 2021
- ARO-HIF2 Shows Signals of Activity, Safety in Clear Cell Renal Cell Carcinoma - Targeted Oncology - July 9th, 2021
- Gene therapy for sickle cell disease: progress and competition - BioPharma Dive - July 9th, 2021
- Xilis Raises $70 Million Series A Financing to Advance Diagnostic and Drug Discovery and Development Platform Leveraging Proprietary MicroOrganoSphere... - July 9th, 2021
- Dr. Sperling on Future Research Directions With Ide-Cel in Multiple Myeloma - OncLive - July 9th, 2021
- More than $25m awarded to Monash researchers for vital medical research - Monash University - July 9th, 2021
- Magnetically-guided delivery of therapeutic stem cells into the brain - Advanced Science News - July 7th, 2021
- Beyond CAR-T: New Frontiers in Living Cell Therapies - UCSF News Services - July 7th, 2021
- Stem cell therapy could make significant impact as opioid alternative - The Pharma Letter - July 7th, 2021
- Institute for Stem Cell Biology and Regenerative Medicine ... - July 5th, 2021
- Home - World Stem Cell Summit - July 5th, 2021
- Stem Cell Therapy & Regenerative Medicine Clearwater, FL ... - July 5th, 2021
- Ethical Issues in Stem Cell Research - July 5th, 2021
- Cell Therapy Global Market Report 2021: COVID-19 Growth and Change to 2030 - ResearchAndMarkets.com - Business Wire - July 3rd, 2021
- Regenerative Therapy Makes Headway in HF ... in the Right Patients - MedPage Today - July 3rd, 2021
- A New Era For FDA Regulation Of Cell And Tissue Products - Law360 - July 3rd, 2021
- Multiple myeloma treatment: Newest options, drugs, and more - Medical News Today - July 3rd, 2021
- Anti-CD22 CAR-T cell therapy as a salvage treatment - OTT | OTT - Dove Medical Press - July 3rd, 2021
- Studies Offer Promising Data on CAR T-cell Therapy in B-ALL, Multiple Myeloma - AJMC.com Managed Markets Network - July 3rd, 2021
- The cell therapy manufacturing market is projected to reach USD 14.5 billion by 2030, growing at - GlobeNewswire - July 3rd, 2021
- Cellular Model of a Developing Mouse Is Built With Spatial Resolution - Technology Networks - July 3rd, 2021
- Gene editor injected into the body treats disease - Science - July 3rd, 2021
- Philippe Moreau, MD, on the Implications of Daratumumab Maintenance for Newly Diagnosed Multiple Myeloma - Cancer Network - July 3rd, 2021
- Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial - The... - July 1st, 2021
- New Publication Provides Further Clarity of MultiStem's Mechanism of Action on Modulating the Inflammatory Response in Critical Care Indications -... - July 1st, 2021
- XNK Therapeutics Reports First Patient Included in Phase II Study in Multiple Myeloma - PRNewswire - July 1st, 2021
- MCL Treatment: Differences Exist Between Trial-Based Recommendations and Real-World Care - Curetoday.com - July 1st, 2021
- Harton improving with stem cell treatment | Sports | thefacts.com - Brazosport Facts - June 29th, 2021
- Kite Announces Yescarta CAR T-cell Therapy Improved Event-Free Survival by 60% Over Chemotherapy Plus Stem Cell Transplant in Second-Line Relapsed or... - June 29th, 2021