I am very pleased to begin this weeks update with news that work just published from our Queen Mary University of London research centre could pave the way for truly personalised treatment for patients diagnosed with glioblastoma multiforme (GBM). The team there has established an entirely new experimental research pipeline to analyse cells derived from brain tumour tissue and compare these with their putative cell of origin from the same patient. Using this powerful technique, they have been able to identify changes in the function of genes that occur in glioblastoma that do not entail a change in the genetic code. Led by Professor Silvia Marino, this clever method has revealed new insights for how glioblastoma develops and identified potential new targets for individualised treatments.
By using a combination of laboratory work and sophisticated analytical computer programmes the team at the Research Centre have identified significant molecular differences that potentially can be exploited to develop new treatments. This innovative approach enables the comparison of normal and malignant cells from the same patient, helping to identify genes that play a role in glioblastoma growth.
There exists strong evidence that glioblastoma cells develop from neural stem cells. However, previous studies have not been able to compare tumour cells and normal cells from the same person. In this study, Professor Marinos team harnessed state-of-the-art stem cell technologies and next-generation DNA sequencing methods to compare glioblastoma cells with neural stem cells from the same patient. Their results have shown how this approach can reveal novel molecular events that go awry when glioblastoma develops, thereby identifying targets for potentially new treatments. Indeed, the team has revealed how some glioblastomas control the movement of regulatory T cells. Moreover, this new approach has identified relevant epigenetic changes that predict response to drugs currently in clinical use. This important finding opens-up opportunities to investigate potential new treatments for glioblastoma.
This is the first time that a comprehensive analysis has been conducted comparing the epigenetic differences between a patients neural stem cells and glioblastoma cells. Further research is required to determine whether this novel approach called SYNGN (syngeneic comparison of GIC and iNSC) can be of value to the clinical management of patients with glioblastoma.
The paper is entitled Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells (SYNGN) in glioblastoma and is published by Nature Communications
Other brain tumour papers of note published this week include work investigating geographical variations in brain/central nervous system (CNS) cancer incidence and mortality and another looking at a distinct subset of paediatric-type supratentorial neuroepithelial tumours
The National Cancer Research Institute (NCRI) is currently seeking patient and carer representatives (consumers) to represent the patient community on the Childrens Research Group, and its 6 associated Subgroups. Two subgroups are responsible for developing research in the Central Nervous System (CNS) and Neuroblastoma.
If you would like to find out more visit the website. The deadline for all applications is Sunday 7th November (23:59pm).
On Tuesday 16 November 2021 - 12:30-13:15 (GMT) Professor Simona Parrinello from University College London (UK), will chair a meeting focused on the importance of translational science in cancer research, specifically in the study of brain cancer, including primary brain tumours (such as glioblastoma) and brain metastasis. Dr Joan Seoane from the Vall dHebron Institute of Oncology (Spain), whose work has been recognised with several awards, will share how his multidisciplinary team of researchers have been looking at the molecular processes that appear with the onset of brain cancer and trying to find treatments to combat it.
We have been working with the actor Phoebe Frances Browns who tells her story of finding herself in the bleakest of times and of discovering gladness in the saddest of moments in her one woman play The Glad Game.
Phoebe was diagnosed with a large, grade 3astrocytomain 2018 after experiencing symptoms, including headaches and tiredness. The incurable tumour is in the area of her brain which controls speech, language and memory. Despite going through surgery, radiotherapy and chemotherapy, Phoebe has continued to forge a successful career on the stage.
The play, which Phoebe began writing whilst in hospital recovering from brain surgery, aims to debunk some of the myths around what life is like for people, particularly young people, living with cancer. It is about a life lived with cancer, but also about creating the life you want in the most difficult of circumstances. There are plans for it to tour in Autumn 2021 and Spring 2022, and Brain Tumour Research is supportive of this play as the charity partner.
She said:I wanted to write and perform a play about life being stranger than fiction; that even after receiving the most devastating news, theres still hilarity and joy to be had. There are still things to be glad about.
There is a digital edition of The Glad Game which can be downloaded and watched until the end of October. A truly exceptional depiction of the patient experience and essential viewing for those researching in this area who wish to get a real understanding of what a brain tumour diagnosis brings.
The next research update will be on 5th November.
Related reading:
If you found this story interesting or helpful,sign up to our weekly e-newsand keep up to date with all the latest from Brain Tumour Research.
Link:
New GBM research pipeline and being glad - Brain Tumour Research
- Stem Cell Science and Human Research Studies Ahead of Cargo Arrival - NASA Blogs - February 18th, 2024
- Stem cell research project to launch into space - Fox Weather - January 24th, 2024
- Breakthrough in cancer research opening up stem cell therapy to more people. How you can get involved - 69News WFMZ-TV - January 20th, 2024
- Stem Cell Research Heading to the ISS on Axiom Mission 3 - ISS National Lab - January 18th, 2024
- No, Rep. Steve Scalise Didn't Vote Against Stem Cell Research From Which He Is Now Benefiting - The Dispatch - January 12th, 2024
- Applications are open for the Maryland Stem Cell Research Fund - Technical.ly - January 4th, 2024
- Global Stem Cell Therapy Market to Reach USD 928.6 Million by 2031: Says Allied Market Research - Yahoo Finance - November 19th, 2023
- Current state of stem cell-based therapies: an overview - PMC - November 3rd, 2023
- Dynamic Stem Cell Therapy Uncovers Research in Advance Regenrative Medicine - Yahoo Finance - November 3rd, 2023
- Research Fellow (Aging and Cancer Stem Cell Laboratory ... - Times Higher Education - October 15th, 2023
- Qkine Collaborates with the Cambridge Stem Cell Institute to Facilitate Same-Day Access to Key Research Products for Researchers at the Cambridge... - September 27th, 2023
- Stem cells: a comprehensive review of origins and emerging clinical ... - September 25th, 2023
- Stem Cell Research and Communicating Science | GBH - GBH News - September 20th, 2023
- Stem cell research reveals the earliest stages of a human life - SBS News - September 10th, 2023
- Stem Cell Therapy Market Size 2023 | Innovative Research Methodologies with Emerging Trends and Opportuni - Benzinga - September 10th, 2023
- Autologous Stem Cell and Non-Stem Cell Based Therapies Market Research, Current Trends, Key Industry Play - Benzinga - September 8th, 2023
- Stem Cell Therapy Market 2023 Business Statistics and Research ... - The Knox Student - August 28th, 2023
- Autologous Stem Cell Based Therapies Market Analysis, Research ... - Chatfield News-Record - July 19th, 2023
- Global Stem Cell Market Projected to Reach $14 Bn by 2028: Ken Research - Yahoo Finance - July 11th, 2023
- Theradaptive Awarded Manufacturing Assistance Grant by the Maryland Stem Cell Research Fund - Benzinga - July 10th, 2023
- Bionano Announces Presentation of OGM Utility Across Stem Cell Therapy Applications at the International Society for Stem Cell Research (ISSCR) Annual... - June 19th, 2023
- Sana Biotechnology Highlights Preclinical Data from Hypoimmune and Fusogen Platforms at the International Society for Stem Cell Research (ISSCR) 2023... - June 17th, 2023
- Induced Pluripotent Stem Cell (iPSC) Global Market Report 2023: Effective Research Programs Hold Key in Roll Out of Advanced iPSC Treatments - Yahoo... - June 17th, 2023
- Lung and heart stem cell research paves way for new COVID-19 treatments - Medical Xpress - June 14th, 2023
- Toxicology PhD student cultivating giant leaps in stem cell research ... - June 4th, 2023
- Harvard Stem Cell Institute (HSCI) - May 26th, 2023
- Findings may lead to improved insulin-secreting cells derived from stem ... - May 26th, 2023
- Cell Press: Stem Cell Reports - May 26th, 2023
- Stem cell research could enable blood to be made in other parts of the body - Medical Xpress - May 26th, 2023
- Construction of myocardial patch with mesenchymal stem cells and poly ... - May 22nd, 2023
- Cedars-Sinai to Send Stem Cells to the Space Station to Aid in the ... - May 22nd, 2023
- researchers expand human blood stem cells | Institute for Stem Cell ... - May 22nd, 2023
- A Look Inside Stem Cells Helps Create Personalized Regenerative ... - May 17th, 2023
- Exclusive Research Report on Msenchymal Stem Cell and Exosome Diagnostics and Therapies Market to Witness Comp - openPR - May 17th, 2023
- The Future of Stem Cell Research: Master of Science in ... - The Daily | Case Western Reserve University - May 10th, 2023
- Exclusive Research Report on Stem Cell Therapy for Diabetes and ... - Digital Journal - May 9th, 2023
- Aging melanocyte stem cells and gray hair | National Institutes of ... - May 5th, 2023
- Mouse hair turns gray when certain stem cells get stuck - May 5th, 2023
- Science-First Skincare Company Michal Morrison Secures Exclusive World-Wide License of Proprietary STEM6 Molecule, Supported by Over 25 Years of... - May 5th, 2023
- BioCentriq and panCELLa execute research agreement to study stem cell-derived Natural Killer cell expansi - Benzinga - May 3rd, 2023
- Hair turning gray? Study finds a stem cell 'glitch' may be the cause - May 1st, 2023
- Elevai Labs Announces Research Grant Award and Partnership to Better Characterize the 'Payload' of ELEVAI's Stem Cell-derived Exosomes - Yahoo Finance - April 27th, 2023
- Why does hair turn gray? A new study says 'stuck' stem cells may ... - NPR - April 27th, 2023
- Study advances understanding of how melanocyte stem cells work to color ... - April 21st, 2023
- Stem cell research and therapy legislation to be replaced, says ... - Bahamas Tribune - April 21st, 2023
- Stem Cell Research (journal) - Wikipedia - April 21st, 2023
- Scientists Are About to Try to Create Stem Cells in Space - April 21st, 2023
- Stem Cell Research & Therapy | Articles - BioMed Central - April 16th, 2023
- Stem Cell Junk Yards Reveal a New Clue About Aging | WIRED - April 16th, 2023
- Global Stem Cells Market Research Report 2023: Implications - April 16th, 2023
- Stem cell research can help people with hard- | EurekAlert! - April 16th, 2023
- University Of Edinburgh's stem cell research gets funding boost - India Education Diary - April 14th, 2023
- Two major stem cell research projects supported with more than ... - University of California, Santa Cruz - April 8th, 2023
- Cancer detection predicts tumors before they form: discovery - March 29th, 2023
- Stem cell therapy: a potential cure for hearing loss? - March 29th, 2023
- Turkey's Only Stem Cell Production Application and Research Center - Expat Guide Turkey - March 24th, 2023
- Stem Cell Research Article, Embryonic Cells Information, Cell Therapy ... - March 24th, 2023
- Scientists create mice with cells from 2 males for 1st time - March 19th, 2023
- QBRI concludes stem cells symposium - Gulf Times - March 17th, 2023
- 2020 California Proposition 14 - Wikipedia - March 17th, 2023
- Stem Cell Reports | Journal | ScienceDirect.com by Elsevier - March 17th, 2023
- Stem cell therapy MSC-NP found to ease inflammatory activity of brain ... - March 12th, 2023
- Stem Cell Research | Office of Research Compliance | SIU - March 12th, 2023
- Heart disease study shows hope for stem cell treatment - March 4th, 2023
- Stem cells drive antler regeneration | Science - March 4th, 2023
- Stem Cell Research: Argumentative Essay - Free Essay Example - Edubirdie - March 4th, 2023
- Stem Cell Research | Thermo Fisher Scientific - US - March 4th, 2023
- Stem cell controversy - Wikipedia - February 28th, 2023
- National Institutes of Health grant funds interdisciplinary ... - February 27th, 2023
- Research Associate in Cancer Stem Cell Research job with ... - Times Higher Education - February 25th, 2023
- Pioneering Stem Cell Research Conference at The Aga Khan ... - The Aga Khan University - February 25th, 2023
- Scientists grapple with ethics of stem cell research - STAT - February 17th, 2023
- Research Associate in Stem Cell Neurobiology job with KINGS ... - Times Higher Education - January 30th, 2023
- Stem cells: past, present, and future | Stem Cell Research & Therapy ... - January 12th, 2023
- Edu Thesis & Essay: Stem cell research outline top writers online! - January 12th, 2023
- Stem Cell Biology Research Program | Johns Hopkins Institute for Cell ... - January 5th, 2023
- Stem cell population identified is vital for bone regeneration: Research - ThePrint - January 5th, 2023
- Leading scientist 'blown away' by UAE advances in stem cell research - The National - December 15th, 2022
- The Stem Cell Assay Market Is Set To Grow At A 20% Annual Rate, Due To The High Prevalence Of Chronic Diseases As Per The Business Research Company's... - December 13th, 2022
- Stem cell and bone marrow transplants - Cancer Research UK - December 9th, 2022
Recent Comments