Canadian Blood Services | Canada’s Lifeline

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Hematopoietic stem cell transplantation – Wikipedia

Medical procedure to replace blood or immune stem cells Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells.[1][2][3][4][5][6] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin).[4][5] It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia.[5] In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. Infection and graft-versus-host disease are major complications of allogeneic HSCT.[5] HSCT remains a dangerous procedure with many possible complications; it is reserved for patients with life-threatening diseases. As survival following the procedure has increased, its use has expanded beyond cancer to autoimmune diseases[7][8] and hereditary skeletal dysplasias, notably malignant infantile osteopetrosis[9][10] and mucopolysaccharidosis.[11] Indications for stem-cell transplantation are: Many recipients of HSCTs are multiple myeloma[15] or leukemia patients[16] who would not benefit from prolonged treatment with, or are already resistant to, chemotherapy.

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Cord blood banking: Definitions, pros, and cons – Medical News Today

Cord blood is the blood from a baby that remains in the umbilical cord and placenta after birth. Cord blood banks store frozen cord blood until someone who is a genetic match requires a transplant. Cord blood contains special cells called hematopoietic stem cells. Hematopoietic stem cells are immature cells that can develop into all types of blood cells, such as red blood cells, white blood cells, and platelets.

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