Impact Analysis of COVID-19 on Stem Cells Market Study 2018-2028 Segmented On The Basis of Product Type, Geographical Analysis, Future Forecast,…

The global stem cells market is driven by various factors which include increasing prevalence and incidence rate of cancer and cancer-related diseases. Rising research and development programs, increasing awareness related to regenerative treatment, increasing the use of biomarkers and growth in biopsy market are also driving the market. The high prevalence of cancer in children is also a key driving factor for stem cell study. The number of stem cell banks has increased exponentially.

The Final Report will cover the impact analysis of COVID-19 on this industry (Global and Regional Market).

The number of hospitals and research centers in developed countries is capable of storing stem cells. Even in countries such as China and India, the growing awareness amongst the professionals and masses is the key driver for the market. India, China, and other emerging nations are also offering stem cell therapies and services and lower cost which is leading to the emergence of medical tourism in the stem cells market.

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The market is segmented on the basis of product type, applications, and technology. The product types consist of adult stem cells, human embryonic stem cells market, induced pluripotent stem cells market, and very small embryonic-like cells market. Applications include regenerative medicines market which is further segmented as cancer regenerative medicines market, orthopedics regenerative medicines market, hematological regenerative medicines market, neurological regenerative medicines market, cardiovascular regenerative medicines market, regenerative medicines market, injuries regenerative medicines market and others regenerative medicines market.

Drug discovery is also a major application. Stem cells market by technology includes bone marrow harvest, apheresis, umbilical blood cord, therapeutic cloning, in vitro fertilization, isolation, cell culture, cryopreservation, and expansion and subculture.

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Geographically, the market is a segment as North America, Europe, Asia Pacific and the rest of the world. North America has the highest market share followed by Europe and the Asia Pacific. The Asia Pacific is expected to report the highest growth rate for the forecasted period. Key companies in the market include STEMCELL technologies, Millipore, Corning, BioTime Inc, Advanced Cell technology Inc, Cellular engineering technologies and other major companies.

How does the report examine the growth drivers and restraints of the Stem Cells Market?

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Company profiles

1. STEMCELL technologies2. Millipore3. Corning4. BioTime Inc5. Advanced Cell Technology Inc6. Cellular engineering technologies7. Cellartis AB8. Angel Biotechnology9. Bioheart Inc10. Cellgene corporation11. Brainstorm cell therapeutics12. Osiris therapeutics13. BD biosciences14. Lonza15. ATCC16. Allcells17. Miltenyi biotec GmBH18. QIAGEN19. Novocell20. Stemgent21. Sigma Aldrich22. Invitrogen23. Nunc24. Peprotec25. R&D systems26. Cellular dynamics international27. ChanTest corporation28. Wiicell research institute29. Hybrid Organ GmBH30. BIOE31. Aastrom Biosciences32. California Stem Cells33. International Stem Cell Corporation34. NeoStem35. NeuralStem36. Medistem37. Apceth38. Cardio3 BioSciences39. TiGenix

This Research Report covers

1. Historical data2. Revenue forecasts, growth rates and CAGR up to 20283. Industry Analysis4. Competitive Analysis5. Key geographic growth data

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Kenneth Research provides market research reports to different individuals, industries, associations, and organizations with the aim of helping them to take prominent decisions. Our research library comprises more than 10,000 research reports provided by more than 15 market research publishers across different industries. Our collection of market research solutions covers both the macro level as well as micro-level categories with relevant and suitable market research titles. As a global market research reselling firm, Kenneth Research provides a significant analysis of various markets with pure business intelligence and consulting services on different industries across the globe. In addition to that, our internal research team always keeps a track of the international and domestic market for any economic changes impacting the products demand, growth, and opportunities for new and existing players.

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COVID-19 Impact and Recovery Analysis on Cell Freezing Media for Cell Therapy Market 2020-2026 by BioLife Solutions, Akron Biotechnology, GE…

Heres recently issued report on the Global Cell Freezing Media for Cell Therapy Market that allows you to offer a brief analysis of the market size, demand, supply chain, distribution channels, futuristic trends, market growth elements and so on. It offers a comprehensive analysis of assorted business aspects like global Cell Freezing Media for Cell Therapy market trends, recent technological advancements, market shares, size and new innovations. What is more, this analytical knowledge has been compiled through knowledge searching techniques like primary and secondary analysis for Cell Freezing Media for Cell Therapy industry. Moreover, an professional team of researchers throws lightweight on numerous static additionally as dynamic aspects of the worldwide Cell Freezing Media for Cell Therapy market.

NOTE: Our reports include the analysis of the impact of COVID-19 on this industry. Our new sample is updated which correspond in new report showing impact of Covid-19 on Industry trends. Also we are offering 20% discount

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Geographically, the worldwide Cell Freezing Media for Cell Therapy market has been analyzed in numerous regions like North America, geographical region, geographical region, Asia-Pacific, Africa, Europe and Asian nation. The worldwide Cell Freezing Media for Cell Therapy market region is dominating this market among the forthcoming future. Worldwide Cell Freezing Media for Cell Therapy market is that the skilled and correct study of assorted business views like key players, key geographies, divers, restraints, opportunities and challenges. This global analysis report has been mass on the concept of assorted market segments and sub-segments associated with the worldwide market.

Global Cell Freezing Media for Cell Therapy market competition by prime manufacturers, with Cell Freezing Media for Cell Therapy sales volume, value (USD/Unit), revenue (Million USD) and market share for each manufacturer. The report provides an in-depth analysis of the worldwide Cell Freezing Media for Cell Therapy Market progressing to cut back time to plug for products and services, cut back operational value, improve accuracy and operational performance. Besides this, the report elaborates crucial aspects such as fresh product establishment, greater expenditure in R&D and increasing demand in the manufacturing differentiable growth opportunities in the Cell Freezing Media for Cell Therapy Market globally.

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The complete profile of the manufacturers are mentioned. And so the capability, production, price, revenue, cost, gross, margin of profit, sales volume, sales revenue, consumption, rate of growth, import and export, future strategies and therefore the technological developments that they are creating are also enclosed among the report. The historical knowledge and forecast knowledge from 2020 to 2026.

Leading companies reviewed in the Cell Freezing Media for Cell Therapy report are:

BioLife SolutionsAkron BiotechnologyGE HealthcareThermo Fisher ScientificBiological IndustriesMerckWAK-Chemie MedicalZenoaq

The Cell Freezing Media for Cell Therapy Market report is segmented into following categories:

The Cell Freezing Media for Cell Therapy market report is segmented into Type by following categories;With FBSWithout FBS

The Cell Freezing Media for Cell Therapy market report is segmented into Application by following categories;Human Embryonic Stem CellsCAR-T Cell TherapyNeural Stem Cell TherapyMesenchymal Stem Cell TherapyHematopoietic Stem Cell TransplantationOther

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The report provides substantial knowledge relating to the market share that every one in every of these firms presently garner across this business, in tandem with the market share that they are expected to amass by the highest of the forecast period. Also, the report elaborates on details regarding the products manufactured by every of these companies, that may facilitate new entrants and outstanding stakeholders work on their competition and strategy portfolios. To not mention, their decision-making method is vulnerable to get easier on account of the actual fact that the Cell Freezing Media for Cell Therapy System market report additionally enumerates a gist of the products value trends and so the profit margins of each firm among the industry.

This will enable the readers to focus on Cell Freezing Media for Cell Therapy market product specifications, current competitive manufacturers in Cell Freezing Media for Cell Therapy market and also the market revenue with gain. Worldwide Industry Analyze Cell Freezing Media for Cell Therapy Market by competitive manufacturers, regions and applications of Cell Freezing Media for Cell Therapy market, forecast up to 2026. This report analyses the scope of Cell Freezing Media for Cell Therapy market. This will be achieved by Cell Freezing Media for Cell Therapy previous historical information, analysing qualitative insights info, demonstrable projections regarding global Cell Freezing Media for Cell Therapy market size.

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Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of…

Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study  The Lancet

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Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of...

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Sales of the Mesenchymal Stem Cells Market to Anticipated to Exceed US$ XX by2020 Bulletin Line – Bulletin Line

Global Mesenchymal Stem Cells market study presents an in-depth scenario Which is segmented according to manufacturers, product type, applications, and areas. This segmentation will provide deep-dive analysis of the Mesenchymal Stem Cells industry for identifying the growth opportunities, development trends and factors limiting the growth of the market. This report offers forecast market information based on previous and current Mesenchymal Stem Cells industry scenarios and growth facets. All the key regions covered in Mesenchymal Stem Cells report are North America, Europe, Asia-Pacific, South America, Middle East and Africa. The Mesenchymal Stem Cells market share and market outlook of each area from 2020-2027 are presented in this report. A deep study of Mesenchymal Stem Cells market dynamics can help the market aspirants in identifying the business opportunities which will lead to accumulation of revenue. This section can effectively determine the Mesenchymal Stem Cells risk and key market driving forces.

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The Mesenchymal Stem Cells report is segmented to provide a clear and Precise view of the international Mesenchymal Stem Cells market statistics and market estimates. Mesenchymal Stem Cells report Information represented in the form of graphs, charts, and figures will show the Mesenchymal Stem Cells growth speed, volume, goal consumer analysis. This report introduces the significant data to all Mesenchymal Stem Cells industry aspirants which will facilitate useful business decisions.

Some of the major companies operating in the global mesenchymal stem cell market are EMD Millipore Corporation, Cell Applications, Inc., Cyagen Biosciences, Inc., Genlantis, Inc., Advanced Cell Technology Incorporated, Stemcell Technologies Inc., Celprogen, Inc., Stemedica Cell Technologies, Aastrom Biosciences and ScienCell Research Laboratories.

Key points covered in the report

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The Mesenchymal Stem Cells report cover following data points:

Part 1: This section enlists the global Mesenchymal Stem Cells marketplace Summary, covering the simple market introduction, market evaluation by kind, software, and regions. The major Mesenchymal Stem Cells producing areas include North America, Europe, Asia-Pacific, Middle-East, and Africa. Mesenchymal Stem Cells industry states and outlook (2020-2027) is introduced in this part. Additionally, Mesenchymal Stem Cells market dynamics stating the opportunities, market risk, and key driving forces are researched.

Part 2: This part covers Mesenchymal Stem Cells manufacturers profile based On their small business overview, product type, and program. Additionally, the sales volume, Mesenchymal Stem Cells product cost, gross margin analysis, and Mesenchymal Stem Cells market share of each participant is profiled in this report.

Part 3 and Part 4: This component presents the Mesenchymal Stem Cells competition Based on sales, earnings, and market share of every manufacturer. Part 4 covers the Mesenchymal Stem Cells market situation based on areas. Region-wise Mesenchymal Stem Cells sales and expansion (2015-2019) is analyzed in this report.

Part 5 and Part 6: These two sections cover the North America and Europes Mesenchymal Stem Cells industry by countries. Under this Mesenchymal Stem Cells earnings, market share of those countries like USA, Canada, and Mexico is supplied. Beneath Europe Mesenchymal Stem Cells report includes, the states such as Germany, UK, France, Russia, Italy, Russia and their sales and growth is covered.

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Sales revenue and expansion for the regions like Asia-Pacific, South America, Middle East & Africa. The earnings and expansion in these areas are introduced within this Mesenchymal Stem Cells business report.

Part 10 and Part 11: This part depicts the Mesenchymal Stem Cells market Share, earnings, sales by product type and application. The Mesenchymal Stem Cells sales growth seen during 2012-2020 is covered in this report.

Associated with Mesenchymal Stem Cells economy (2020-2027) for each area. The sales channels such as direct and indirect Mesenchymal Stem Cells marketing, traders, distributors, and future trends are presented within this report.

Part 14 and Part 15: These components present Mesenchymal Stem Cells market crucial Research findings and conclusion, study methodology, and information sources are covered.

Therefore, Global Mesenchymal Stem Cells report is a whole blend covering all The very important market aspects.

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Sales of the Mesenchymal Stem Cells Market to Anticipated to Exceed US$ XX by2020 Bulletin Line - Bulletin Line

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Allogeneic Mesenchymal stem cells Market is on Course to Grow at a CAGR of XX% Over the Forecast Period 2018 2028 – 3rd Watch News

A new intelligence report Allogeneic Mesenchymal stem cells Market has been recently added to Adroit Market Research collection of top-line market research reports. Global Allogeneic Mesenchymal stem cells Market report is a meticulous all-inclusive analysis of the market that offers access to direct first-hand insights on the growth trail of market in near term and long term. On the basis of factual information sourced from authentic industry experts and extensive primary industry research, the report offers insights on the historic growth pattern of Allogeneic Mesenchymal stem cells Market and current market scenario. It then provides short- and long-term market growth projections.

Projections are purely based on the detailed analysis of key market dynamics that are expected to influence Allogeneic Mesenchymal stem cells Market performance and their intensity of impacting market growth over the course of assessment period.

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In addition to evaluation of dynamics, the report provides in-depth examination of key industry trends that are expected to act more prominently in global Allogeneic Mesenchymal stem cells Market. The study also offers valued information about the existing and upcoming growth opportunities in Allogeneic Mesenchymal stem cells Market that the key players and new market entrants can capitalize on.

Competitive companies and manufacturers in global market

key players operating in the Allogeneic Mesenchymal stem cells market are Aastrom Biosciences, Inc. Mesoblast Ltd., Celgene Corporation, and StemCells, Inc.

The report covers exhaustive analysis on:

Regional analysis includes

Report Highlights:

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Opportunity assessment offered in this Allogeneic Mesenchymal stem cells Market report is important in terms of understanding the lucrative areas of investment, which prove to be the actionable insights for leading market players, suppliers, distributors, and other stakeholders in Allogeneic Mesenchymal stem cells Market.

In-depth global Allogeneic Mesenchymal stem cells Market taxonomy presented in this report provides detailed insights about each of the market segments and their sub-segments, which are categorized based on t par various parameters. An exhaustive regional analysis of global Allogeneic Mesenchymal stem cells Market breaks down global market landscape into key geographies.

Regional outlook and country-wise analysis of Allogeneic Mesenchymal stem cells Market allows for the evaluation of multi-faceted performance of market in all the key economies. This information intends to offer a broader scope of report to readers and identify the most relevant profitable areas in global market place.

Key Regions and Countries Covered in Global Allogeneic Mesenchymal stem cells Market Report-

Taxonomy and geographical analysis of the global Allogeneic Mesenchymal stem cells Market enables readers to spot profits in existing opportunities and capture upcoming growth opportunities even before they approach the market place. The analysis offered in report is purely intended to unroll the economic, social, regulatory and political scenarios of the market specific to each region and country, which could help potential market entrants in Allogeneic Mesenchymal stem cells Market landscape to understand the nitty-gritty of target market areas and devise their strategies accordingly.

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Allogeneic Mesenchymal stem cells Market Table of Contents

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Allogeneic Mesenchymal stem cells Market is on Course to Grow at a CAGR of XX% Over the Forecast Period 2018 2028 - 3rd Watch News

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Global Jaw Crushers Market 2020 Analyzed With Trends And Opportunities By 2025 – 3rd Watch News

The report titled Jaw Crushers Market Research 2020 begins from overview of industry chain structure, and describes industry environment, and analyses market size of Jaw Crushers. Initially, the report focuses on the current state of the Jaw Crushers market and then the detailed analysis has been provided based on a systematic and detailed segmentation and sub-segmentation. It identifies the dynamics affecting each segment within it. Jaw Crushers market report profiles some of the key technological developments in the recent times.

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In order to forecast and strengthen the productivity of the Jaw Crushers industry, a detailed study is necessary, which has been explained in the report. The Jaw Crushers industry report summarizes the market insights that are key drivers for growth of the Jaw Crushers sales market over the forecast period (2020-2025). The report is confident in meeting clients need and expectations as we have used innovative business models that focus on delivering high-quality contents. The report studies the Jaw Crushers market in terms of product type, size, and region. Growth behavior in the past of key segments under each criterion is examined, using which their market size and revenue contribution has estimated. The leading players in the Jaw Crushers market have been profiled in this report.

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The report covers crucial entities of the Jaw Crushers market such as market share, wide variety of applications, market trends, demand and supply, market growth outlook, industry value and volume, manufacturing capacity and price ratio of the Jaw Crushers market during the estimated period from 2015 to 2025.

The Jaw Crushers Market Report deals with following key objectives:

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The following points give the overview of the market analysis, focusing on thorough study of the Jaw Crushers Market Research Report:

For market chain analysis, the Jaw Crushers report shades light on marketing channels, upstream raw materials, downstream client survey, market development trend and proposals which specifically comprises valuable information on major raw materials suppliers, distributors, major manufacturing equipment suppliers, and key consumers with their contact information. Furthermore, the report deploys the SWOT analysis tool so that you can try to be one step ahead of your competitors. The report will be beneficial for entrepreneurs, individuals, merchants, large organizations, and start-ups to secure funding.

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs.

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Global Jaw Crushers Market 2020 Analyzed With Trends And Opportunities By 2025 - 3rd Watch News

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Hitachi and ThinkCyte to Develop an AI-driven Cell Analysis | ARC Advisory – ARC Viewpoints

Hitachi, Ltd and ThinkCyte, Inc. announced that they have entered into a collaboration focused on developing an artificial intelligence (AI)-driven cell analysis and sorting system. Hitachi and ThinkCyte are promoting collaboration with pharmaceutical companies and research institutes working in the field of regenerative medicine and cell therapy to expedite the development of the system toward commercialization.

Founded in 2016 and headquartered in Tokyo, Japan, ThinkCyte, is a biotechnology company that develops life science research, diagnostics, and treatments using integrated multidisciplinary technologies. It has been performing research and development focused on high-throughput single cell analysis and sorting technology to precisely analyze and isolate target cells. ThinkCyte has developed the Ghost Cytometry technology to achieve high-throughput and high-content single cell sorting and has been conducting collaborative research projects with multiple pharmaceutical companies and research institutes to utilize this technology in life science and medical fields.

Hitachi has been providing large-scale automated induced pluripotent stem (iPS) cell culture equipment, cell processing facilities (CPFs), manufacturing execution systems(MES), and biosafety cabinets among other products to pharmaceutical companies and research institutes, and has developed a value chain to meet a variety of customer needs in the regenerative medicine and cell therapy industry. Hitachi has also been carrying out collaborative research projects with universities, research institutes, and other companies to develop core technologies for pharmaceutical manufacturing instruments and in vitro diagnostic medical devices, prototyping for mass production, and working on manufacturing cost reduction and the development of stable and reliable instruments.

Hitachi and ThinkCyte have initiated a joint development of the AI-driven cell analysis and sorting system based on their respective technologies, expertise, and know-how. By combining ThinkCyte's high-throughput and high-content label-free single cell sorting technology and Hitachi's know-how and capability to producing stably operative instruments on a large scale, the two companies will together develop a novel reliable system to enable high-speed label-free cell isolation with high accuracy, which has been difficult to achieve with the existing cell sorting techniques, and to realize stable, low-cost and large-scale production of cells for regenerative medicine and cell therapy.

Hitachi and ThinkCyte will further advance partnerships with pharmaceutical companies and research institutes that have been developing and manufacturing regenerative medicines and cell therapy products in Japan and other countries where demand is expected to be significant, such as North America, in order to make this technology a platform for the production of regenerative medicines and cell therapy products.

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Hitachi and ThinkCyte to Develop an AI-driven Cell Analysis | ARC Advisory - ARC Viewpoints

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Stem Cell And Regenerative Therapy Market : Segmentation, Industry Trends and Development size COVID-19 2024 – Kentucky Journal 24

he globalstem cell and regenerative medicines marketshould grow from $21.8 billion in 2019 to reach $55.0 billion by 2024 at a compound annual growth rate (CAGR) of 20.4% for the period of 2019-2024.

Report Scope:

The scope of this report is broad and covers various type of product available in the stem cell and regenerative medicines market and potential application sectors across various industries. The current report offers a detailed analysis of the stem cell and regenerative medicines market.

The report highlights the current and future market potential of stem cell and regenerative medicines and provides a detailed analysis of the competitive environment, recent development, merger and acquisition, drivers, restraints, and technology background in the market. The report also covers market projections through 2024.

The report details market shares of stem cell and regenerative medicines based on products, application, and geography. Based on product the market is segmented into therapeutic products, cell banking, tools and reagents. The therapeutics products segments include cell therapy, tissue engineering and gene therapy. By application, the market is segmented into oncology, cardiovascular disorders, dermatology, orthopedic applications, central nervous system disorders, diabetes, others

The market is segmented by geography into the following regions: North America, Europe, Asia-Pacific, South America, and the Middle East and Africa. The report presents detailed analyses of major countries such as the U.S., Canada, Mexico, Germany, the U.K. France, Japan, China and India. For market estimates, data is provided for 2018 as the base year, with forecasts for 2019 through 2024. Estimated values are based on product manufacturers total revenues. Projected and forecasted revenue values are in constant U.S. dollars, unadjusted for inflation.

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Report Includes:

28 data tables An overview of global markets for stem cell and regenerative medicines Analyses of global market trends, with data from 2018, estimates for 2019, and projections of compound annual growth rates (CAGRs) through 2024

Details of historic background and description of embryonic and adult stem cells Information on stem cell banking and stem cell research A look at the growing research & development activities in regenerative medicine Coverage of ethical issues in stem cell research & regulatory constraints on biopharmaceuticals Comprehensive company profiles of key players in the market, including Aldagen Inc., Caladrius Biosciences Inc., Daiichi Sankyo Co. Ltd., Gamida Cell Ltd. and Novartis AG

Summary

The global market for stem cell and regenerative medicines was valued at REDACTED billion in 2018. The market is expected to grow at a compound annual growth rate (CAGR) of REDACTED to reach approximately REDACTED billion by 2024. Growth of the global market is attributed to the factors such as growingprevalence of cancer, technological advancement in product, growing adoption of novel therapeuticssuch as cell therapy, gene therapy in treatment of chronic diseases and increasing investment fromprivate players in cell-based therapies.

In the global market, North America held the highest market share in 2018. The Asia-Pacific region is anticipated to grow at the highest CAGR during the forecast period. The growing government funding for regenerative medicines in research institutes along with the growing number of clinical trials based on cell-based therapy and investment in R&D activities is expected to supplement the growth of the stem cell and regenerative market in Asia-Pacific region during the forecast period.

Reasons for Doing This Study

Global stem cell and regenerative medicines market comprises of various products for novel therapeutics that are adopted across various applications. New advancement and product launches have influenced the stem cell and regenerative medicines market and it is expected to grow in the near future. The biopharmaceutical companies are investing significantly in cell-based therapeutics. The government organizations are funding research and development activities related to stem cell research. These factors are impacting the stem cell and regenerative medicines market positively and augmenting the demand of stem cell and regenerative therapy among different application segments. The market is impacted through adoption of stem cell therapy. The key players in the market are investing in development of innovative products. The stem cell therapy market is likely to grow during the forecast period owing to growing investment from private companies, increasing in regulatory approval of stem cell-based therapeutics for treatment of chronic diseases and growth in commercial applications of regenerative medicine.

Products based on stem cells do not yet form an established market, but unlike some other potential applications of bioscience, stem cell technology has already produced many significant products in important therapeutic areas. The potential scope of the stem cell market is now becoming clear, and it is appropriate to review the technology, see its current practical applications, evaluate the participating companies and look to its future.

The report provides the reader with a background on stem cell and regenerative therapy, analyzes the current factors influencing the market, provides decision-makers the tools that inform decisions about expansion and penetration in this market.

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Stem Cell And Regenerative Therapy Market : Segmentation, Industry Trends and Development size COVID-19 2024 - Kentucky Journal 24

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13 promising Covid-19 treatments emerging from Israel – The Yucatan Times

In parallel to vaccine research, theres an urgent need for effective treatments for the respiratory disease caused by the SARS-CoV-2 coronavirus.

ISRAEL (Scientists across the globe are working on vaccines to prevent Covid-19 infection. After initial vaccines are approved, there is an urgent need for effective treatments for the respiratory disease caused by the SARS-CoV-2 coronavirus.

Most potential treatments target the life-threatening lung inflammation typical of covid-19 severe cases. Its caused by a phenomenon called a cytokine storm.

Cytokines are proteins that trigger inflammation as a natural response to infection. In response to a virus overload, in this case, in the lungs, the immune system activates a storm of cytokines. Too many cytokines lead to too much inflammation, which can damage the lungs and cause respiratory distress.

Israeli hospitals were among the first anywhere to use dexamethasone, a steroid drug, to stop cytokines storms and reduce lung inflammation in severely ill Covid-19 patients. However, steroids can suppress the immune response too actively.

Additionally, an Israeli hospital is among the first to do a randomized, double-blind, placebo-controlled clinical trial of ivermectin, a drug to treat parasitic infections in people and animals, to see if it can shorten the duration of the disease if given to Covid-19 patients immediately after diagnosis.

Israelis are also formulating novel therapeutics of their own. Here are 13 potential Israeli treatments using a variety of approaches.

PluristemOn June 11, Pluristem Therapeutics of Haifa announced a multicenter Phase 2 US Food and Drug Administration (FDA) efficacy and safety study of its PLX-PAD cells for treating severe Covid-19 complicated by acute respiratory distress syndrome (ARDS).

PLX, an injected regenerative placenta-derived cell therapy, stimulates the immune systems natural regulatory T cells and M2 macrophages, possibly preventing or reversing a cytokine storm. PLX cells potentially reduce the incidence or severity of Covid-19 pneumonia and pneumonitis.

Pluristem has treated Covid-19 patients under compassionate use programs in the United States and Israel. Initial data from 18 patients showed that 75% were off mechanical ventilation within 28 days.

PLX cells are available off-the-shelf and once commercialized, can be manufactured in large-scale quantities, offering a key advantage in addressing a global pandemic, the company said.

SilkimJerusalem-based Silkim Pharma recently submitted Coronzot, its novel treatment for Covid-19 patients with moderate to severe symptoms, to the FDAs Investigational New Drug (IND) program.

IND designation would give Silkim permission to start human clinical trials and ship Coronzot across state lines before a marketing application has been approved.

Coronzots novel mechanism targets a pivotal factor in cytokine storms. It removes an inflammatory overaccumulation of labile iron and replaces it with a minute amount of gallium or zinc.

This not only suppresses the storm but also inhibits viral proteins that attack the lungs and heart. Gallium inhibits virus replication and promotes apoptosis (self-destruction) of already invaded cells. Zinc helps suppress inflammatory reactions and enzymes that enable coronavirus replication.

The company is actively engaged in the FDA process. We look forward to finalizing the IND and then moving towards conducting clinical studies of Coronzot for Covid-19, said Silkim Pharma CEO Dror Chevion.

RedHill BiopharmaRedHill Biopharma, based in Raleigh, North Carolina, and Tel Aviv, is racing to advance our development program with opaganib for Covid-19, according to a June 10 statement by Dr. Mark L. Levitt, RedHill medical director.

RedHill acquired opaganib from US-based Apogee Biotechnology, which developed this oral drug to fight cancer, inflammation, and viruses.

RedHill has seen encouraging preliminary findings from six Israeli Covid-19 patients given opaganib under compassionate use to reduce lung inflammation. All were weaned from supplemental oxygen and discharged from the hospital without having to receive mechanical ventilation.

RedHill plans a multicenter, randomized, double-blind, parallel-arm, placebo-controlled Phase 2/3 clinical study on 270 US patients with severe Covid-19 pneumonia.

We are expanding the development program to Russia and additional European countries, parallel with the US clinical study, to accelerate the collection of robust data on the potential efficacy of opaganib against Covid-19, said Levitt.

The company is working with government agencies worldwide to allow more patients access to the investigational drug through clinical studies and compassionate use programs.

InnoCanInnoCan founders, from left, Ron Mayron, Iris Bincovich, Yoram Drucker. Photo by Rotem LahavInnoCan Pharma Israel and Tel Aviv University tech-transfer company Ramot are collaborating to develop a new CBD-loaded exosome technology to fight lung inflammation.

Exosomes, small particles created from stem cells, can act as homing missiles targeting specific damaged organs and facilitating cell-to-cell communication.

Combining the cell-healing properties of exosomes with the anti-inflammatory properties of the cannabis-derived compound CBD is expected to have a strong synergetic effect. The treatment is administrated by inhalation.

Stero BiotechsStero Biotechs of Bnei Brak has started a small clinical trial at Rabin Medical Center in Petah Tikva on the tolerability, safety, and efficacy of CBD-enhanced steroid treatment for hospitalized Covid-19 patients.

Steroid treatment is usually the first or second line of treatment for hospitalized patients. CBD enhances the therapeutic effect of steroid treatment and treats the bio-mechanism affected by the virus, the company explained.

Eybna and CannaSoulTwo Israeli cannabis R & D firms, Eybna Technologies and CannaSoul Analytics, develop a proprietary terpene formulation for modulating cytokine storms.

Terpenes are organic compounds found in cannabis and other plants. Studies suggest they can be effective antiviral agents.

CannaSouls Cytokine Storm Assay (from its Myplant-Bio subsidiary) will aid in optimizing and customizing Eybnas novel NT-VRL inhaled formulation for treatment and prevention of viral infections in high-risk populations and actively ill patients.

The FDA considers this assay as a good predictor for cytokine storm response and immunotoxicity, and it is commonly required in the development of biological treatments, according to CannaSoul Chairman and CSO Prof. Dedi Meiri.

The NT-VRL formulation intended to be used via inhalation, said Eybna CEO Nadav Eyal. This delivery method dramatically increases the terpenes bioavailability by directly contacting the infected cells in the respiratory system.

CannaSoul aims to identify other cannabis molecules capable of suppressing a cytokine storm in response to Covid-19 without completely suppressing the immune system. It is also studying how cannabis molecules could modulate the ACE2 receptor, which allows the virus to inject its genetic expression into human cells.

KamadaBased in Rehovot, Kamada has begun supplying its experimental plasma-derived Hyperimmune IgG therapy for compassionate use in severe Covid-19 cases in Israel.

The treatment is based on plasma donated by recovered Israeli Covid-19 patients. One critically ill patient at Hadassah Medical Center showed initial improvement after having the experimental IgG therapy but ultimately did not survive.

During the third quarter of this year, Kamada expects to start a Phase 1/2 clinical study in hospitalized Covid-19 patients in Israel and hold a pre-IND meeting with the FDA to expand clinical development in the United States in partnership with Kedrion Biopharma.

Kedrion is collecting plasma from recovered American Covid-19 patients at 23 FDA-approved centers across the United States. This will be used by Kamada to manufacture additional batches of the product.

To the best of our knowledge, Kamada is the first company globally to complete manufacturing of a plasma-derived IgG product for the treatment of Covid-19, said Kamada CEO Amir London.

Israel Institute for Biological ResearchThe government-run Israel Institute for Biological Research (IIBR) announced in May that analogs of two drugs for Gauchers disease proved effective against SARS-CoV-2.

This drug cocktail is made up of the FDA-approved Cerdelga and an analog of the second drug in advanced stages of the approval process.

The IIBR study on cell cultures demonstrated that the two-drug treatment significantly reduced the coronaviruss replication capacity and the destruction of the infected cell. This potential treatment is currently being tested in animals infected with the coronavirus.

The IIRB also isolated several critical coronavirus antibodies that successfully neutralized aggressive coronavirus in lab tests. These could form the basis of future treatment following further testing.

PepticomBased in Jerusalem, Pepticom computationally designs novel peptide drug candidates using artificial intelligence. The company raised $5 million last year.

Three months ago, Pepticom began implementing its proprietary AI technology on various coronavirus proteins to identify novel peptides that inhibit the interaction between the spike protein of SARS-Cov-2 and the ACE2 receptor thereby stopping the virus from entering the cell.

CEO Immanuel Lerner says three such proteins have already been identified and are being validated in the lab.

Using AI is a fast way to find these peptides, which are less expensive and easier to produce than antibodies, Lerner tells ISRAEL21c. Many parties are interested in looking at our results and finding ways to develop this further.

Bonus BioGroupIn April, Bonus BioGroup initiated a preclinical study of MesenCure, its unique drug for treating acute and life-threatening respiratory distress in coronavirus and pneumonia patients.

MesenCure consists of activated mesenchymal stromal (stem) cells from healthy adult donors. The activation of these MSCs is intended to boost their ability to reduce lung inflammation, promote regeneration of the diseased lung tissue, and alleviate respiratory and other symptoms in the lungs.

The development of MesenCure relies on more than a decade of related experience and technologies that Bonus BioGroup has used in developing its lead product, a tissue-engineered bone graft, also based on MSCs.

With the current coronavirus outbreak, Bonus BioGroup has started tissue culture studies into the potential of these MSCs, further activated, to alleviate inflammation, including in the lungs, and possibly attenuate the cytokine storm in COVID-19 patients, the company explained.

The preclinical study in several animal models is expected to be completed in the third quarter of 2020. The company said preliminary results indicate that following the treatment with MesenCure, the microscopic appearance of the treated lungs was similar to a healthy lung, and a significant improvement in additional related parameters was achieved.

Bonus BioGroup presented these results to 1,800 scientists, physicians, and public opinion leaders at the International Society for Cell & Gene Therapy virtual conference in May.

NanoGhostTechnion-Israel Institute of Technology Prof. Marcelle Machluf developed a drug-delivery technology that uses reconstructed mesenchymal stem cells as nano-vesicles to transport medicine directly to a target.

NanoGhost is the startup she established to commercialize the technology, which has proven successful in treating pancreatic, lung, breast, prostate, and brain cancer in mice. The NanoGhost technology has been patented in the United States and Europe, with additional patents pending in India and China.

Now, Machluf is adapting her technology to create decoy NanoGhosts that attract and entrap the coronavirus, making for a less severe infection. She explains it in the video below.

EnlivexEnlivex Therapeutics of Ness Ziona is developing Allocetra, a novel immunotherapy medication to treat organ dysfunction and acute multiple organ failure associated with sepsis and Covid-19, as well as solid tumors.

Allocetra rebalances a severely unbalanced immune system by engaging with the immune systems own regulation mechanisms. It is designed to restore a safe immune balance following a cytokine storm.

Enlivex is starting to recruit Covid-19 patients in Israel and in the United States to test the potential effect of Allocetra on moderate to severe cases. A patent from the Japan Patent Office is expected during the third quarter of 2020.

Weizmann Institute of ScienceOrganic chemist Nir London of the Weizmann Institute of Science in Rehovot is co-leading a collaborative project to identify small molecules that can bind to and inhibit a protease enzyme that the SARS-CoV-2 virus needs to reproduce.

London and his research team had previously developed an advanced method for identifying potential inhibitors for numerous proteins.

So far, we have made close to 800 compounds and tested more than 650 and keep getting closer to sufficiently potent inhibitors, London tells ISRAEL21c.

These inhibitors will be further investigated for their potential as a starting point for new drugs against the coronavirus.

London is working with researchers from Oxford University, Memorial Sloan Kettering Cancer Center, University of British Columbia, and Californian-based biotech company.

The Yucatan TimesNewsroom

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